1H-Benzimidazole-5-carboxylicacid,6-amino-,methylester

Base Information

• Chemical Name: 1H-Benzimidazole-5-carboxylicacid,6-amino-,methylester
• CAS No.: 181284-95-7
• Molecular Formula: C₉H₉N₃O₂
• Molecular Weight: 191.189
• Mol file: 181284-95-7.mol

Synonyms:5-Amino-6-methoxycarbonylbenzimidazole

Chemical Property of 1H-Benzimidazole-5-carboxylicacid,6-amino-,methylester

Chemical Property:

• PSA: 81.00000
• LogP: 1.51290

Purity/Quality:

6-AMINO-1H-BENZIMIDAZOLE-5-CARBOXYLIC ACID METHYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Benzimidazole-5-carboxylicacid,6-amino-,methylester

There total 3 articles about 1H-Benzimidazole-5-carboxylicacid,6-amino-,methylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

methyl 5-nitro-1H-benzimidazole-6-carboxylate (895581-42-7) → methyl 5-amino-1H-benzimidazole-6-carboxylate (181284-95-7)

Guidance literature:

With hydrogen; palladium on activated charcoal; In acetic acid; for 1h; Heating;

DOI:10.1002/hlca.200690062

Reference yield:

1H-benzimidazole-6-carboxylic acid (15788-16-6) → methyl 5-amino-1H-benzimidazole-6-carboxylate (181284-95-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 96 percent / SOCl₂ / 12 h / 50 °C

2: 68 percent / HNO₃ / H₂SO₄ / 12 h / 50 °C

3: 98 percent / H₂ / Pd/C / acetic acid / 1 h / Heating

With thionyl chloride; hydrogen; nitric acid; palladium on activated charcoal; In sulfuric acid; acetic acid;

DOI:10.1002/hlca.200690062

Reference yield:

methyl 1H-benzo[d]imidazole-6-carboxylate (26663-77-4) → methyl 5-amino-1H-benzimidazole-6-carboxylate (181284-95-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 68 percent / HNO₃ / H₂SO₄ / 12 h / 50 °C

2: 98 percent / H₂ / Pd/C / acetic acid / 1 h / Heating

With hydrogen; nitric acid; palladium on activated charcoal; In sulfuric acid; acetic acid;

DOI:10.1002/hlca.200690062

upstream raw materials:

methyl 5-nitro-1H-benzimidazole-6-carboxylate

1H-benzimidazole-6-carboxylic acid

methyl 1H-benzo[d]imidazole-6-carboxylate

Refernces