Technology Process of (3S,11 aR)-8-bromo-3-methyl-6-[(phenyl-methyl)oxy]-2,3,11,11a-tetrahydro[1,3]oxazolo[3,2-a] pyrido[1,2-d]pyrazine-5,7-dione
There total 12 articles about (3S,11 aR)-8-bromo-3-methyl-6-[(phenyl-methyl)oxy]-2,3,11,11a-tetrahydro[1,3]oxazolo[3,2-a] pyrido[1,2-d]pyrazine-5,7-dione which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
N-Bromosuccinimide;
In
1-methyl-pyrrolidin-2-one;
at 20 ℃;
for 2.5h;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: potassium carbonate / acetonitrile / 5 h / 80 °C
2.1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / -60 °C
2.2: 1 h / -60 °C
3.1: triethylamine; methanesulfonyl chloride / tetrahydrofuran / 30 °C
3.2: 0.5 h / 30 °C
4.1: sodium periodate; rhodium(III) chloride hydrate; water / acetonitrile; ethyl acetate / 1 h / 25 °C
4.2: 1 h / 25 °C
5.1: pyridine / ethanol / 8.5 h / 65 - 80 °C
6.1: sodium hydrogencarbonate / 1-methyl-pyrrolidin-2-one; water / 4 h / 20 °C
7.1: sodium periodate; acetic acid; water / acetonitrile / 2 h / 20 °C
8.1: acetic acid / acetonitrile; methanol / 4 h / 70 °C
9.1: N-Bromosuccinimide / 1-methyl-pyrrolidin-2-one / 2.5 h / 20 °C
With
pyridine; sodium periodate; N-Bromosuccinimide; rhodium(III) chloride hydrate; water; sodium hydrogencarbonate; potassium carbonate; acetic acid; methanesulfonyl chloride; triethylamine; lithium hexamethyldisilazane;
In
tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; ethanol; water; ethyl acetate; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / -60 °C
1.2: 1 h / -60 °C
2.1: triethylamine; methanesulfonyl chloride / tetrahydrofuran / 30 °C
2.2: 0.5 h / 30 °C
3.1: sodium periodate; rhodium(III) chloride hydrate; water / acetonitrile; ethyl acetate / 1 h / 25 °C
3.2: 1 h / 25 °C
4.1: pyridine / ethanol / 8.5 h / 65 - 80 °C
5.1: sodium hydrogencarbonate / 1-methyl-pyrrolidin-2-one; water / 4 h / 20 °C
6.1: sodium periodate; acetic acid; water / acetonitrile / 2 h / 20 °C
7.1: acetic acid / acetonitrile; methanol / 4 h / 70 °C
8.1: N-Bromosuccinimide / 1-methyl-pyrrolidin-2-one / 2.5 h / 20 °C
With
pyridine; sodium periodate; N-Bromosuccinimide; rhodium(III) chloride hydrate; water; sodium hydrogencarbonate; acetic acid; methanesulfonyl chloride; triethylamine; lithium hexamethyldisilazane;
In
tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; ethanol; water; ethyl acetate; acetonitrile;