Technology Process of Boc-Phe-Phe-Gly-His-Met-NH2
There total 6 articles about Boc-Phe-Phe-Gly-His-Met-NH2 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 60 percent / 80percent hydrazine / methanol / 96 h / Ambient temperature
2: 1.) 1M HCl, NaNO2, 2.) triethylamine / 1.) glacial acetic acid, 0 deg C, 15 min, 2.) DMF, 0 deg C, 6 d
3: 1.) triethylamine, DPPA / 1.) DMF, 0 deg C, 20 min, 2.) DMF, a) 0 deg C, 3 h, b) RT, 7 d
With
hydrogenchloride; diphenyl-phosphinic acid; hydrazine hydrate; triethylamine; sodium nitrite;
In
methanol;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 85 percent / HBr / acetic acid / 1 h / Ambient temperature
2: 1.) triethylamine, DPPA / 1.) DMF, 0 deg C, 20 min, 2.) DMF, a) 0 deg C, 3 h, b) RT, 7 d
With
diphenyl-phosphinic acid; hydrogen bromide; triethylamine;
In
acetic acid;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: conc. aq. NH3 / 72 h
2: 85 percent / HBr / acetic acid / 1 h / Ambient temperature
3: 1.) triethylamine, DPPA / 1.) DMF, 0 deg C, 20 min, 2.) DMF, a) 0 deg C, 3 h, b) RT, 7 d
With
ammonium hydroxide; diphenyl-phosphinic acid; hydrogen bromide; triethylamine;
In
acetic acid;
