5-{5-(3-Cyano-5-fluorophenyl)-3-[(4-oxoimidazolidin-1-yl)carbonyl]-1H-pyrazol-1-yl}-2-fluorobenzenecarbonitrile

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Chemical Name:5-{5-(3-Cyano-5-fluorophenyl)-3-[(4-oxoimidazolidin-1-yl)carbonyl]-1H-pyrazol-1-yl}-2-fluorobenzenecarbonitrile
CAS No.:1187917-91-4
Molecular Formula:C₂₁H₁₂F₂N₆O₂
Molecular Weight:418.362
Hs Code.:

Synonyms:5-{5-(3-Cyano-5-fluorophenyl)-3-[(4-oxoimidazolidin-1-yl)carbonyl]-1H-pyrazol-1-yl}-2-fluorobenzenecarbonitrile

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Chemical Property of 5-{5-(3-Cyano-5-fluorophenyl)-3-[(4-oxoimidazolidin-1-yl)carbonyl]-1H-pyrazol-1-yl}-2-fluorobenzenecarbonitrile

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Technology Process of 5-{5-(3-Cyano-5-fluorophenyl)-3-[(4-oxoimidazolidin-1-yl)carbonyl]-1H-pyrazol-1-yl}-2-fluorobenzenecarbonitrile

There total 5 articles about 5-{5-(3-Cyano-5-fluorophenyl)-3-[(4-oxoimidazolidin-1-yl)carbonyl]-1H-pyrazol-1-yl}-2-fluorobenzenecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 1187919-27-2
imidazolidin-4-one trifluoroacetate

: 1187919-35-2
1-(3-Cyano-4-fluorophenyl)-5-(3-cyano-5-fluorophenyl)-1H-pyrazole-3-carboxylic acid

: 1187917-91-4
5-{5-(3-Cyano-5-fluorophenyl)-3-[(4-oxoimidazolidin-1-yl)carbonyl]-1H-pyrazol-1-yl}-2-fluorobenzenecarbonitrile

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 179898-34-1
3-bromo-5-fluorobenzonitrile

: 1187917-91-4
5-{5-(3-Cyano-5-fluorophenyl)-3-[(4-oxoimidazolidin-1-yl)carbonyl]-1H-pyrazol-1-yl}-2-fluorobenzenecarbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / Inert atmosphere; Reflux

1.2: 2 h / 20 °C

2.1: lithium hexamethyldisilazane / hexane; diethyl ether / 1 h / -78 °C / Inert atmosphere

2.2: 20 °C

3.1: hydrogenchloride / water; N,N-dimethyl acetamide / 20 h / 20 °C

4.1: lithium hydroxide / tetrahydrofuran / 5 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / tetrahydrofuran / 20 °C

With hydrogenchloride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; N-ethyl-N,N-diisopropylamine; lithium hydroxide; lithium hexamethyldisilazane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; diethyl ether; hexane; N,N-dimethyl acetamide; water; toluene;

Reference yield:

: 1187919-34-1
Ethyl 1-(3-cyano-4-fluorophenyl)-5-(3-cyano-5-fluorophenyl)-1H-pyrazole-3-carboxylate

: 1187917-91-4
5-{5-(3-Cyano-5-fluorophenyl)-3-[(4-oxoimidazolidin-1-yl)carbonyl]-1H-pyrazol-1-yl}-2-fluorobenzenecarbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide / tetrahydrofuran / 5 h / 20 °C

2: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / tetrahydrofuran / 20 °C

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran;