(2R,3R)-2-hydroxy-1-(2-methoxyphenyl)-3-(2-methylphenyl)-3-(N-diphenylphosphinoylamino)-1-propanone

Base Information

• Chemical Name: (2R,3R)-2-hydroxy-1-(2-methoxyphenyl)-3-(2-methylphenyl)-3-(N-diphenylphosphinoylamino)-1-propanone
• CAS No.: 528838-69-9
• Molecular Formula: C₂₉H₂₈NO₄P
• Molecular Weight: 485.519
• Mol file: 528838-69-9.mol

Synonyms:(2R,3R)-2-hydroxy-1-(2-methoxyphenyl)-3-(2-methylphenyl)-3-(N-diphenylphosphinoylamino)-1-propanone

Chemical Property of (2R,3R)-2-hydroxy-1-(2-methoxyphenyl)-3-(2-methylphenyl)-3-(N-diphenylphosphinoylamino)-1-propanone

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of (2R,3R)-2-hydroxy-1-(2-methoxyphenyl)-3-(2-methylphenyl)-3-(N-diphenylphosphinoylamino)-1-propanone

There total 2 articles about (2R,3R)-2-hydroxy-1-(2-methoxyphenyl)-3-(2-methylphenyl)-3-(N-diphenylphosphinoylamino)-1-propanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-hydroxy-1-(2-methoxyphenyl)ethanone (224321-19-1) + (E)-N-(2-methylbenzylidene)-P,P-diphenylphosphinic amide → (2R,3R)-2-hydroxy-1-(2-methoxyphenyl)-3-(2-methylphenyl)-3-(N-diphenylphosphinoylamino)-1-propanone (528838-69-9)

Guidance literature:

With (S,S)bis(2,2'-dihydroxy[1,1']binaphthalenyl-3-ylmethyl)ether; 3 A molecular sieve; diethylzinc; In tetrahydrofuran; hexane; dichloromethane; at -20 ℃; for 6h;

DOI:10.1021/ja034787f

Reference yield:

2-hydroxy-1-(2-methoxyphenyl)ethanone (224321-19-1) + (E)-N-(2-methylbenzylidene)-P,P-diphenylphosphinic amide → C29H28NO4P + C29H28NO4P + (2R,3R)-2-hydroxy-1-(2-methoxyphenyl)-3-(2-methylphenyl)-3-(N-diphenylphosphinoylamino)-1-propanone (528838-69-9)

Guidance literature:

With (S)-3-(3-hydroxynaphthalen-2-ylmethoxymethyl)-1,1'-bi-2-naphthol; diethylzinc; In tetrahydrofuran; hexane; at -20 ℃; for 5h; Further Variations:; Reagents; Solvents; Temperatures; reaction times; Product distribution;

DOI:10.1002/anie.200500425

Reference yield: 84.0%

bis(trichloromethyl) carbonate (32315-10-9) + (2R,3R)-2-hydroxy-1-(2-methoxyphenyl)-3-(2-methylphenyl)-3-(N-diphenylphosphinoylamino)-1-propanone (528838-69-9) → (4R,5R)-5-(o-anisoyl)-4-(2-methylphenyl)-2-oxazolidinone (528838-80-4)

Guidance literature:

(2R,3R)-2-hydroxy-1-(2-methoxyphenyl)-3-(2-methylphenyl)-3-(N-diphenylphosphinoylamino)-1-propanone; With hydrogenchloride; In tetrahydrofuran; at 20 ℃; for 1h;

bis(trichloromethyl) carbonate; With pyridine; In dichloromethane; at -78 ℃; for 0.5h;

DOI:10.1021/ja0482435

upstream raw materials:

2-hydroxy-1-(2-methoxyphenyl)ethanone

Downstream raw materials:

(4R,5R)-5-(o-anisoyl)-4-(2-methylphenyl)-2-oxazolidinone