N-[4-((3-bromo-1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)-3-fluorophenyl]-2,2,2-trifluoroacetamide

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Chemical Name:N-[4-((3-bromo-1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)-3-fluorophenyl]-2,2,2-trifluoroacetamide
CAS No.:869335-66-0
Molecular Formula:C₂₃H₁₆BrF₄N₃O₃S
Molecular Weight:570.362
Hs Code.:

Synonyms:N-[4-((3-bromo-1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)-3-fluorophenyl]-2,2,2-trifluoroacetamide

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Chemical Property of N-[4-((3-bromo-1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)-3-fluorophenyl]-2,2,2-trifluoroacetamide

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Technology Process of N-[4-((3-bromo-1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)-3-fluorophenyl]-2,2,2-trifluoroacetamide

There total 1 articles about N-[4-((3-bromo-1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)-3-fluorophenyl]-2,2,2-trifluoroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 869335-65-9
N-(4-[(3-bromo-1H-pyrrolo[2,3-b]pyridin-4-yl)methyl]-3-fluorophenyl)-2,2,2-trifluoroacetamide

: 98-59-9
p-toluenesulfonyl chloride

: 869335-66-0
N-[4-((3-bromo-1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)-3-fluorophenyl]-2,2,2-trifluoroacetamide

Guidance literature:: N-(4-[(3-bromo-1H-pyrrolo[2,3-b]pyridin-4-yl)methyl]-3-fluorophenyl)-2,2,2-trifluoroacetamide; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.25h;

p-toluenesulfonyl chloride; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 1h;

Reference yield: 35.0%

: 869335-66-0
N-[4-((3-bromo-1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)-3-fluorophenyl]-2,2,2-trifluoroacetamide

: 557-21-1
dicyanozinc

: 869335-67-1
4-(4-amino-2-fluorobenzyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile

Guidance literature:: N-[4-((3-bromo-1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)-3-fluorophenyl]-2,2,2-trifluoroacetamide; dicyanozinc; With zinc diacetate; water; zinc; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1,1'-bis(diphenylphosphino)ferrocene; In DMF (N,N-dimethyl-formamide); at 100 ℃; for 20h;

With lithium hydroxide; water; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 20h;

Reference yield:

: bis(diphenylphosphino)ferrocene

: 869335-66-0
N-[4-((3-bromo-1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)-3-fluorophenyl]-2,2,2-trifluoroacetamide

: 869335-67-1
4-(4-amino-2-fluorobenzyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile

Guidance literature:: With lithium hydroxide; zinc diacetate; zinc; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;