4-(4-Phenoxyphenyl)piperidine

Base Information

• Chemical Name: 4-(4-Phenoxyphenyl)piperidine
• CAS No.: 181207-55-6
• Molecular Formula: C17H19 N O
• Molecular Weight: 253.344
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID10454373
• Nikkaji Number: J1.195.601G
• Wikidata: Q82275866
• Mol file: 181207-55-6.mol

Synonyms:4-(4-phenoxyphenyl)piperidine;181207-55-6;4-(4-PHENOXY-PHENYL)-PIPERIDINE;4-(4-phenoxyphenyl)-piperidine;SCHEMBL949252;DTXSID10454373;MTMOLUVQNWNTBV-UHFFFAOYSA-N;MFCD04115000;AKOS015954797;AB19428;CS-0341859;EN300-1861374;A812596

Chemical Property of 4-(4-Phenoxyphenyl)piperidine

Chemical Property:

• Boiling Point: 378.0±42.0 °C(Predicted)
• PKA: 10.20±0.10(Predicted)
• PSA: 21.26000
• Density: 1.067±0.06 g/cm3(Predicted)
• LogP: 4.27470
• XLogP3: 3.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 253.146664230
• Heavy Atom Count: 19
• Complexity: 248

Purity/Quality:

97% ^*data from raw suppliers

4-(4-Phenoxy-phenyl)-piperidine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CNCCC1C2=CC=C(C=C2)OC3=CC=CC=C3

Technology Process of 4-(4-Phenoxyphenyl)piperidine

There total 8 articles about 4-(4-Phenoxyphenyl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

→ 4-(4-Phenoxyphenyl)piperidine (181207-55-6) + N-tert-Butyloxycarbonyl-4-hydroxy-4-(4-phenoxyphenyl)piperidine (171350-04-2)

Guidance literature:

Reference yield: 92.0%

N-benzyl-4-(4-phenoxyphenyl)-4-piperidinol (202604-70-4) → 4-(4-Phenoxyphenyl)piperidine (181207-55-6)

Guidance literature:

N-benzyl-4-(4-phenoxyphenyl)-4-piperidinol; With trifluoroacetic acid; at 130 ℃; for 0.25h; Microwave irradiation;

With hydrogen; palladium 10% on activated carbon; In methanol; at 75 ℃; for 5h; under 3000.3 Torr;

Reference yield: 88.0%

4-(4-phenoxyphenyl)-1,2,3,6-tetrahydropyridine (171350-05-3) → 4-(4-Phenoxyphenyl)piperidine (181207-55-6)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 12h;

DOI:10.1016/S0960-894X(99)00516-8

upstream raw materials:

4-(4-phenoxyphenyl)-1,2,3,6-tetrahydropyridine

4-Bromodiphenyl ether

N-tert-butyloxycarbonylpiperidin-4-one

N-tert-Butyloxycarbonyl-4-hydroxy-4-(4-phenoxyphenyl)piperidine

Downstream raw materials:

C₂₀H₂₃NO₅S