N-(S-S-biotinyl)-N'-[3,5-bis(ethoxycarbonylmethoxy)benzoyl]ethane-1,2-diamine

Base Information

• Chemical Name: N-(S-S-biotinyl)-N'-[3,5-bis(ethoxycarbonylmethoxy)benzoyl]ethane-1,2-diamine
• CAS No.: 918300-32-0
• Molecular Formula: C₃₂H₄₇N₅O₁₀S₃
• Molecular Weight: 757.951
• Mol file: 918300-32-0.mol

Synonyms:N-(S-S-biotinyl)-N'-[3,5-bis(ethoxycarbonylmethoxy)benzoyl]ethane-1,2-diamine

Chemical Property of N-(S-S-biotinyl)-N'-[3,5-bis(ethoxycarbonylmethoxy)benzoyl]ethane-1,2-diamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(S-S-biotinyl)-N'-[3,5-bis(ethoxycarbonylmethoxy)benzoyl]ethane-1,2-diamine

There total 1 articles about N-(S-S-biotinyl)-N'-[3,5-bis(ethoxycarbonylmethoxy)benzoyl]ethane-1,2-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

NHS-SS-biotin (122266-55-1) + ethyl 2-{3-[(2-aminoethyl)carbamoyl]-5-(2-ethoxy-2-oxoethoxy)phenoxy}acetate trifluoroacetic acid salt → N-(S-S-biotinyl)-N'-[3,5-bis(ethoxycarbonylmethoxy)benzoyl]ethane-1,2-diamine (918300-32-0)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

DOI:10.1021/ja0614159

Reference yield:

N-(S-S-biotinyl)-N'-[3,5-bis(ethoxycarbonylmethoxy)benzoyl]ethane-1,2-diamine (918300-32-0) → {3-Carboxymethoxy-5-[2-(3-{2-[5-((3aR,6S,6aS)-2-oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoylamino]-ethyldisulfanyl}-propionylamino)-ethylcarbamoyl]-phenoxy}-acetic acid

Guidance literature:

With sodium hydroxide; In methanol; water; at 20 ℃; for 2h;

DOI:10.1021/ja0614159

Reference yield:

N-(S-S-biotinyl)-N'-[3,5-bis(ethoxycarbonylmethoxy)benzoyl]ethane-1,2-diamine (918300-32-0) → N-(S-S-biotinyl)-N'-[3,5-bis((N-succinimidyl)oxycarbonylmethoxy)benzoyl]ethane-1,2-diamine

Guidance literature:

Multi-step reaction with 2 steps

1: NaOH / methanol; H₂O / 2 h / 20 °C

2: pyridine / 20 °C

With pyridine; sodium hydroxide; In methanol; water;

DOI:10.1021/ja0614159

upstream raw materials:

NHS-SS-biotin