1H-Indeno[1,2-b]pyrazine,2,3,4,4a,9,9a-hexahydro-1-methyl-,cis-(9CI)

Base Information

• Chemical Name: 1H-Indeno[1,2-b]pyrazine,2,3,4,4a,9,9a-hexahydro-1-methyl-,cis-(9CI)
• CAS No.: 181034-51-5
• Molecular Formula: C₁₂H₁₆N₂
• Molecular Weight: 188.272
• Mol file: 181034-51-5.mol

Synonyms:1H-Indeno[1,2-b]pyrazine,2,3,4,4a,9,9a-hexahydro-1-methyl-,cis-(9CI);(4AS,9AR)-1-METHYL-2,3,4,4A,9,9A-HEXAHYDRO-1H-INDENO[1,2-B]PYRAZINE

Chemical Property of 1H-Indeno[1,2-b]pyrazine,2,3,4,4a,9,9a-hexahydro-1-methyl-,cis-(9CI)

Chemical Property:

• PSA: 15.27000
• LogP: 1.45410

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Indeno[1,2-b]pyrazine,2,3,4,4a,9,9a-hexahydro-1-methyl-,cis-(9CI)

There total 12 articles about 1H-Indeno[1,2-b]pyrazine,2,3,4,4a,9,9a-hexahydro-1-methyl-,cis-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

cis-4,4a,9,9a-tetrahydro-1-methyl-1H-indeno<1,2-b>pyrazine-2,3-dione → cis-2,3,4,4a,9,9a-hexahydro-1-methyl-1H-indeno<1,2-b>pyrazine (181034-50-4,181034-51-5)

Guidance literature:

With lithium aluminium tetrahydride; aluminium trichloride; In diethyl ether; Ambient temperature;

DOI:10.1039/P19930001307

Reference yield: 74.0%

trans-2,3,4,4a,9,9a-hexahydro-4-(4-methoxybenzyl)-1-methyl-1H-indeno<1,2-b>pyrazine → trans-2,3,4,4a,9,9a-hexahydro-1-methyl-1H-indeno[1,2-b]pyrazine (181034-50-4,181034-51-5)

Guidance literature:

With methyl-phenyl-thioether; sulfuric acid; trifluoroacetic acid; for 1.25h; Heating;

DOI:10.1039/P19930001307

Reference yield: 60.0%

2-((1S,2S)-2-Methylamino-indan-1-ylamino)-ethanol → trans-2,3,4,4a,9,9a-hexahydro-1-methyl-1H-indeno[1,2-b]pyrazine (181034-50-4,181034-51-5)

Guidance literature:

With tetrachloromethane; N,N,N,N,N,N-hexamethylphosphoric triamide; sodium iodate; triethylamine; sodium iodide; In N,N-dimethyl-formamide; for 1h; Ambient temperature;

upstream raw materials:

trans-1-chloro-2-ethoxycarbonylaminoindane

N-Carbethoxy-1,2-iminoinden

Refernces

• 1、 Orlek, Barry S.,Lightowler, Diane. "Stereoselective Construction of Vicinal Diamines. Part 2. Synthesis of Indenopyrazines". . p. 1307 - 1312. Retrieved 2007/10/02.