(S)-(-)-4-Bromo-β-<<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>benzenebutanol

Base Information

Chemical Name:(S)-(-)-4-Bromo-β-<<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>benzenebutanol
CAS No.:127633-54-9
Molecular Formula:C₁₇H₂₉BrO₂Si
Molecular Weight:373.406
Hs Code.:

Synonyms:(S)-(-)-4-Bromo-β-<<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>benzenebutanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-(-)-4-Bromo-β-<<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>benzenebutanol

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Technology Process of (S)-(-)-4-Bromo-β-<<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>benzenebutanol

There total 8 articles about (S)-(-)-4-Bromo-β-<<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>benzenebutanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 127633-62-9
(S)-(-)-4-Bromo-β-<<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>benzenebutanol acetate

: 127633-54-9
(S)-(-)-4-Bromo-β-<<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>benzenebutanol

Guidance literature:: With sodium hydroxide; at 25 ℃;
DOI:10.1016/S0040-4039(01)93875-4

Reference yield:

: (RS)-4-Bromo-β-<<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>benzenebutanol acetate

: 127633-54-9
(S)-(-)-4-Bromo-β-<<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>benzenebutanol

: (R)-4-Bromo-β-<<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>benzenebutanol

Guidance literature:: With sodium hydroxide; In methanol; Yield given. Yields of byproduct given. Title compound not separated from byproducts; Ambient temperature;
DOI:10.1021/jo00102a031

Reference yield:

: 4654-39-1
4-bromophenethanol

: 127633-54-9
(S)-(-)-4-Bromo-β-<<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>benzenebutanol

Guidance literature:: Multi-step reaction with 6 steps

1: Et₃N

2: 90 percent / NaH

3: 75 percent / LiAlH₄ / diethyl ether

4: 90 percent / with porcine pancreatic lipase (PPL, Sigma type II, no. 3126)

5: 88 percent / imidazole / CH₂Cl₂

6: 79 percent / aq. NaOH / 25 °C

With 1H-imidazole; sodium hydroxide; lithium aluminium tetrahydride; sodium hydride; triethylamine; In diethyl ether; dichloromethane;
DOI:10.1016/S0040-4039(01)93875-4