1-(1H-indazol-4-yl)-3-[(1S,2R,4S,5S)-4-phenylbicyclo[3.1.0]hex-2-yl]urea

Base Information

Chemical Name:1-(1H-indazol-4-yl)-3-[(1S,2R,4S,5S)-4-phenylbicyclo[3.1.0]hex-2-yl]urea
CAS No.:1401075-22-6
Molecular Formula:C₂₀H₂₀N₄O
Molecular Weight:332.405
Hs Code.:

Synonyms:1-(1H-indazol-4-yl)-3-[(1S,2R,4S,5S)-4-phenylbicyclo[3.1.0]hex-2-yl]urea

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Chemical Property of 1-(1H-indazol-4-yl)-3-[(1S,2R,4S,5S)-4-phenylbicyclo[3.1.0]hex-2-yl]urea

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Technology Process of 1-(1H-indazol-4-yl)-3-[(1S,2R,4S,5S)-4-phenylbicyclo[3.1.0]hex-2-yl]urea

There total 4 articles about 1-(1H-indazol-4-yl)-3-[(1S,2R,4S,5S)-4-phenylbicyclo[3.1.0]hex-2-yl]urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.7%

: 735330-50-4
4-(2,5-dioxopyrrolidin-1-yl-oxycarbonylamino)indazole-1-carboxylic acid methyl ester

: 1401075-28-2
(1S,2R,4S,5S)-4-phenylbicyclo[3.1.0]hexan-2-amine

: 1401075-22-6
1-(1H-indazol-4-yl)-3-[(1S,2R,4S,5S)-4-phenylbicyclo[3.1.0]hex-2-yl]urea

Guidance literature:: 4-(2,5-dioxopyrrolidin-1-yl-oxycarbonylamino)indazole-1-carboxylic acid methyl ester; (1S,2R,4S,5S)-4-phenylbicyclo[3.1.0]hexan-2-amine; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

With sodium hydroxide; In methanol; water; for 0.333333h;

Reference yield:

: 1401075-26-0
N-((1S,2R,4S,5S)-4-phenylbicyclo[3.1.0]hexan-2-yl)acetamide

: 1401075-22-6
1-(1H-indazol-4-yl)-3-[(1S,2R,4S,5S)-4-phenylbicyclo[3.1.0]hex-2-yl]urea

Guidance literature:: Multi-step reaction with 2 steps

1.1: water; barium(II) hydroxide / dimethyl sulfoxide / 10 h / 95 °C

2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.25 h / 20 °C

2.2: 0.33 h

With water; N-ethyl-N,N-diisopropylamine; barium(II) hydroxide; In dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 1401075-57-7
(1R,4S)-4-phenylcyclopent-2-enamine

: 1401075-22-6
1-(1H-indazol-4-yl)-3-[(1S,2R,4S,5S)-4-phenylbicyclo[3.1.0]hex-2-yl]urea

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine / dichloromethane / 0.25 h / 0 °C

2.1: dichloromethane / 3 h / -10 - 20 °C

3.1: water; barium(II) hydroxide / dimethyl sulfoxide / 10 h / 95 °C

4.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.25 h / 20 °C

4.2: 0.33 h

With pyridine; water; N-ethyl-N,N-diisopropylamine; barium(II) hydroxide; In dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;