3-(3,4-dichlorophenyl)-1,3-dihydro-1'-methylspiro[benzo(c)thiophene-1,4'-piperidine]

Base Information

Chemical Name:3-(3,4-dichlorophenyl)-1,3-dihydro-1'-methylspiro[benzo(c)thiophene-1,4'-piperidine]
CAS No.:72364-18-2
Molecular Formula:C₁₉H₁₉Cl₂NS
Molecular Weight:364.339
Hs Code.:

Synonyms:3-(3,4-dichlorophenyl)-1,3-dihydro-1'-methylspiro[benzo(c)thiophene-1,4'-piperidine]

Suppliers and Price of 3-(3,4-dichlorophenyl)-1,3-dihydro-1'-methylspiro[benzo(c)thiophene-1,4'-piperidine]

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 3-(3,4-dichlorophenyl)-1,3-dihydro-1'-methylspiro[benzo(c)thiophene-1,4'-piperidine]

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

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Hazard Codes:

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Technology Process of 3-(3,4-dichlorophenyl)-1,3-dihydro-1'-methylspiro[benzo(c)thiophene-1,4'-piperidine]

There total 4 articles about 3-(3,4-dichlorophenyl)-1,3-dihydro-1'-methylspiro[benzo(c)thiophene-1,4'-piperidine] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 72364-17-1
4-(3,4-Dichloro-benzylsulfanyl)-4-(2-fluoro-phenyl)-1-methyl-piperidine

: 72364-18-2
3-(3,4-dichlorophenyl)-1,3-dihydro-1'-methylspiro[benzo(c)thiophene-1,4'-piperidine]

Guidance literature:: With sodium methylsulfinylmethanide; In dimethyl sulfoxide; for 1h; Ambient temperature;
DOI:10.1021/jm00133a016

Reference yield:

: 1445-73-4
1-Methyl-4-piperidone

: 72364-18-2
3-(3,4-dichlorophenyl)-1,3-dihydro-1'-methylspiro[benzo(c)thiophene-1,4'-piperidine]

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) n-BuLi / 1.) THF, -70 deg C, 1 h, 2.) THF, from -60 deg C to RT

2: BF₃, glacial AcOH / 15 h / 60 °C

3: dimsyl sodium / dimethylsulfoxide / 1 h / Ambient temperature

With n-butyllithium; boron trifluoride; sodium methylsulfinylmethanide; acetic acid; In dimethyl sulfoxide;
DOI:10.1021/jm00133a016

Reference yield:

: 1072-85-1
o-fluorobromobenzene

: 72364-18-2
3-(3,4-dichlorophenyl)-1,3-dihydro-1'-methylspiro[benzo(c)thiophene-1,4'-piperidine]

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) n-BuLi / 1.) THF, -70 deg C, 1 h, 2.) THF, from -60 deg C to RT

2: BF₃, glacial AcOH / 15 h / 60 °C

3: dimsyl sodium / dimethylsulfoxide / 1 h / Ambient temperature

With n-butyllithium; boron trifluoride; sodium methylsulfinylmethanide; acetic acid; In dimethyl sulfoxide;
DOI:10.1021/jm00133a016