(3R,5aS,10aS)-3-ethyloxycarbonyl-10a-(2'-amino)-phenyl-5,10-dioxooctahydro-5H-pyrrolo[1,2-a][1,3]thiazolo[3,2-d]pyrazine

Base Information

• Chemical Name: (3R,5aS,10aS)-3-ethyloxycarbonyl-10a-(2'-amino)-phenyl-5,10-dioxooctahydro-5H-pyrrolo[1,2-a][1,3]thiazolo[3,2-d]pyrazine
• CAS No.: 1236853-38-5
• Molecular Formula: C₁₈H₂₁N₃O₄S
• Molecular Weight: 375.448
• Mol file: 1236853-38-5.mol

Synonyms:(3R,5aS,10aS)-3-ethyloxycarbonyl-10a-(2'-amino)-phenyl-5,10-dioxooctahydro-5H-pyrrolo[1,2-a][1,3]thiazolo[3,2-d]pyrazine

Chemical Property of (3R,5aS,10aS)-3-ethyloxycarbonyl-10a-(2'-amino)-phenyl-5,10-dioxooctahydro-5H-pyrrolo[1,2-a][1,3]thiazolo[3,2-d]pyrazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3R,5aS,10aS)-3-ethyloxycarbonyl-10a-(2'-amino)-phenyl-5,10-dioxooctahydro-5H-pyrrolo[1,2-a][1,3]thiazolo[3,2-d]pyrazine

There total 3 articles about (3R,5aS,10aS)-3-ethyloxycarbonyl-10a-(2'-amino)-phenyl-5,10-dioxooctahydro-5H-pyrrolo[1,2-a][1,3]thiazolo[3,2-d]pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

C33H31N3O6S (1236853-28-3) → (3R,5aS,10aS)-3-ethyloxycarbonyl-10a-(2'-amino)-phenyl-5,10-dioxooctahydro-5H-pyrrolo[1,2-a][1,3]thiazolo[3,2-d]pyrazine (1236853-38-5)

Guidance literature:

With piperidine; In dichloromethane; for 1h;

DOI:10.1016/j.bmc.2010.04.079

Reference yield: 50.0%

C23H29N3O6S (1236853-21-6) → (3R,5aS,10aR)-3-ethyloxycarbonyl-3-(2'-amino)-phenyl-5,10-dioxooctahydro-5H-pyrrolo[1,2-a][1,3]thiazolo[3,4-d]pyrazine (1236853-48-7) + (3S,5aS,10aR)-3-ethyloxycarbonyl-3-(2'-amino)-phenyl-5,10-dioxooctahydro-5H-pyrrolo[1,2-a][1,3]thiazolo[3,4-d]pyrazine (1236853-77-2) + (3R,5aS,10aS)-3-ethyloxycarbonyl-10a-(2'-amino)-phenyl-5,10-dioxooctahydro-5H-pyrrolo[1,2-a][1,3]thiazolo[3,2-d]pyrazine (1236853-38-5)

Guidance literature:

With trifluoroacetic acid; In acetonitrile; for 2h;

DOI:10.1016/j.bmc.2010.04.079

Reference yield: 16.0%

C23H29N3O6S (1236853-21-6) → ethyl (3RS,4'R)-2-oxospiro[indoline-3,2'-thiazolidine]-4'-carboxylate (1236853-14-7) + (3S,5aS,10aR)-3-ethyloxycarbonyl-3-(2'-amino)-phenyl-5,10-dioxooctahydro-5H-pyrrolo[1,2-a][1,3]thiazolo[3,4-d]pyrazine (1236853-77-2) + (3R,5aS,10aS)-3-ethyloxycarbonyl-10a-(2'-amino)-phenyl-5,10-dioxooctahydro-5H-pyrrolo[1,2-a][1,3]thiazolo[3,2-d]pyrazine (1236853-38-5)

Guidance literature:

With trifluoroacetic acid; In acetonitrile; for 24h;

DOI:10.1016/j.bmc.2010.04.079

upstream raw materials:

C₂₃H₂₉N₃O₆S

C₃₃H₃₁N₃O₆S