D-myo-Inositol, 1-O-(4-methoxyphenyl)methyl-2,6-bis-O-(phenylmethyl)-, trisbis(phenylmethyl) phosphate

Base Information

Chemical Name:D-myo-Inositol, 1-O-(4-methoxyphenyl)methyl-2,6-bis-O-(phenylmethyl)-, trisbis(phenylmethyl) phosphate
CAS No.:180794-91-6
Molecular Formula:C70H71 O16 P3
Molecular Weight:1261.25
Hs Code.:

Synonyms:D-myo-Inositol, 1-O-(4-methoxyphenyl)methyl-2,6-bis-O-(phenylmethyl)-, trisbis(phenylmethyl) phosphate

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Chemical Property of D-myo-Inositol, 1-O-(4-methoxyphenyl)methyl-2,6-bis-O-(phenylmethyl)-, trisbis(phenylmethyl) phosphate

Chemical Property:

PSA：200.63000
LogP:16.54550

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of D-myo-Inositol, 1-O-(4-methoxyphenyl)methyl-2,6-bis-O-(phenylmethyl)-, trisbis(phenylmethyl) phosphate

There total 12 articles about D-myo-Inositol, 1-O-(4-methoxyphenyl)methyl-2,6-bis-O-(phenylmethyl)-, trisbis(phenylmethyl) phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 108549-23-1
Dibenzyl N,N-diisopropylphosphoramidite

: 180794-90-5
(-)-2,6-di-O-benzyl-1-O-(p-methoxybenzyl)-myo-inositol

: 180794-91-6
(-)-2,6-di-O-benzyl-1-O-(p-methoxybenzyl)-myo-inositol 3,4,5-tris(dibenzyl phosphate)

Guidance literature:: Dibenzyl N,N-diisopropylphosphoramidite; With 1H-tetrazole; In dichloromethane; at 23 ℃; for 0.5h;

(-)-2,6-di-O-benzyl-1-O-(p-methoxybenzyl)-myo-inositol; In dichloromethane; at 23 ℃; for 12h;

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at -40 ℃; for 0.5h;
DOI:10.1021/jo960602u

Reference yield:

: Phosphorous acid dibenzyl ester (1S,2S,3R,4S,5R,6R)-2,4-bis-benzyloxy-5,6-bis-(bis-benzyloxy-phosphanyloxy)-3-(4-methoxy-benzyloxy)-cyclohexyl ester

: 180794-91-6
(-)-2,6-di-O-benzyl-1-O-(p-methoxybenzyl)-myo-inositol 3,4,5-tris(dibenzyl phosphate)

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; acetonitrile; at 0 ℃; for 2h; Yield given;
DOI:10.1016/S0008-6215(96)00211-X

Reference yield:

: 140148-49-8
(-)-3,4,5-tri-O-allyl-6-O-benzyl-myo-inositol

: 180794-91-6
(-)-2,6-di-O-benzyl-1-O-(p-methoxybenzyl)-myo-inositol 3,4,5-tris(dibenzyl phosphate)

Guidance literature:: Multi-step reaction with 4 steps

1.1: di-n-butyltin oxide / toluene / 2 h / Heating

1.2: 96 percent / CsF / dimethylformamide / 17 h / -15 - 20 °C

2.1: NaH / dimethylformamide / 0.5 h / 0 °C

2.2: 98 percent / dimethylformamide / 40 °C

3.1: 82 percent / p-toluenesulfonic acid; water / Pd/C / methanol / 2 h / Heating

4.1: 1H-tetrazole / CH₂Cl₂ / 0.5 h / 23 °C

4.2: CH₂Cl₂ / 12 h / 23 °C

4.3: 95 percent / m-chloroperoxybenzoic acid / CH₂Cl₂ / 0.5 h / -40 °C

With 1H-tetrazole; water; sodium hydride; di(n-butyl)tin oxide; toluene-4-sulfonic acid; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene; 1.1: coordination / 1.2: Etherification / 2.1: Metallation / 2.2: Etherification / 3.1: Hydrolysis / 4.1: Addition / 4.2: phosphorylation / 4.3: Oxidation;
DOI:10.1021/jo960602u