1-[3-(2,2-difluoro-2-phenyl-ethoxy)-4-methoxy-benzoylamino]-cycloheptanecarboxylic acid methyl ester

Base Information

Chemical Name:1-[3-(2,2-difluoro-2-phenyl-ethoxy)-4-methoxy-benzoylamino]-cycloheptanecarboxylic acid methyl ester
CAS No.:1298046-34-0
Molecular Formula:C₂₅H₂₉F₂NO₅
Molecular Weight:461.506
Hs Code.:

Synonyms:1-[3-(2,2-difluoro-2-phenyl-ethoxy)-4-methoxy-benzoylamino]-cycloheptanecarboxylic acid methyl ester

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Chemical Property of 1-[3-(2,2-difluoro-2-phenyl-ethoxy)-4-methoxy-benzoylamino]-cycloheptanecarboxylic acid methyl ester

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Technology Process of 1-[3-(2,2-difluoro-2-phenyl-ethoxy)-4-methoxy-benzoylamino]-cycloheptanecarboxylic acid methyl ester

There total 6 articles about 1-[3-(2,2-difluoro-2-phenyl-ethoxy)-4-methoxy-benzoylamino]-cycloheptanecarboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 476415-67-5
trifluoromethanesulfonic acid 2,2-difluoro-2-phenyl-ethyl ester

: 1298047-78-5
1-(3-hydroxy-4-methoxy-benzoylamino)-cycloheptanecarboxylic acid methyl ester

: 1298046-34-0
1-[3-(2,2-difluoro-2-phenyl-ethoxy)-4-methoxy-benzoylamino]-cycloheptanecarboxylic acid methyl ester

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; acetone; at 20 ℃; for 72h; Inert atmosphere;

Reference yield:

: 645-08-9,74309-78-7
Isovanillic acid

: 1298046-34-0
1-[3-(2,2-difluoro-2-phenyl-ethoxy)-4-methoxy-benzoylamino]-cycloheptanecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 3 h / 140 °C / Inert atmosphere

1.2: 1 h / 100 °C / Inert atmosphere; Reflux

2.1: N-ethyl-N,N-diisopropylamine; O-<[cyano(ethoxycarbonyl)methylene]amino>-1,1,3,3-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

3.1: potassium carbonate / methanol / 20 °C / Inert atmosphere

3.2: Inert atmosphere

4.1: potassium carbonate / N,N-dimethyl-formamide; acetone / 72 h / 20 °C / Inert atmosphere

With O-<[cyano(ethoxycarbonyl)methylene]amino>-1,1,3,3-tetramethyluronium tetrafluoroborate; potassium carbonate; N-ethyl-N,N-diisopropylamine; In methanol; N,N-dimethyl-formamide; acetone;

Reference yield:

: 60444-56-6
3-acetoxy-4-methoxybenzoic acid

: 1298046-34-0
1-[3-(2,2-difluoro-2-phenyl-ethoxy)-4-methoxy-benzoylamino]-cycloheptanecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine; O-<[cyano(ethoxycarbonyl)methylene]amino>-1,1,3,3-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

2.1: potassium carbonate / methanol / 20 °C / Inert atmosphere

2.2: Inert atmosphere

3.1: potassium carbonate / N,N-dimethyl-formamide; acetone / 72 h / 20 °C / Inert atmosphere

With O-<[cyano(ethoxycarbonyl)methylene]amino>-1,1,3,3-tetramethyluronium tetrafluoroborate; potassium carbonate; N-ethyl-N,N-diisopropylamine; In methanol; N,N-dimethyl-formamide; acetone;