2-[(2-({2-[(2-aminoacetyl)amino]acetyl}amino)-5-{bis[2-(diphenylphosphoryl)ethyl]amino}-5-oxopentanoyl)amino]acetic acid

Base Information

Chemical Name:2-[(2-({2-[(2-aminoacetyl)amino]acetyl}amino)-5-{bis[2-(diphenylphosphoryl)ethyl]amino}-5-oxopentanoyl)amino]acetic acid
CAS No.:1472004-41-3
Molecular Formula:C₃₉H₄₅N₅O₈P₂
Molecular Weight:773.763
Hs Code.:

Synonyms:2-[(2-({2-[(2-aminoacetyl)amino]acetyl}amino)-5-{bis[2-(diphenylphosphoryl)ethyl]amino}-5-oxopentanoyl)amino]acetic acid

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Chemical Property of 2-[(2-({2-[(2-aminoacetyl)amino]acetyl}amino)-5-{bis[2-(diphenylphosphoryl)ethyl]amino}-5-oxopentanoyl)amino]acetic acid

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Technology Process of 2-[(2-({2-[(2-aminoacetyl)amino]acetyl}amino)-5-{bis[2-(diphenylphosphoryl)ethyl]amino}-5-oxopentanoyl)amino]acetic acid

There total 4 articles about 2-[(2-({2-[(2-aminoacetyl)amino]acetyl}amino)-5-{bis[2-(diphenylphosphoryl)ethyl]amino}-5-oxopentanoyl)amino]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1472004-40-2
tert-butyl 12-(3-{bis[2-(diphenylphosphoryl)ethyl]amino}-3-oxopropyl)-2,2-dimethyl-4,7,10,13-tetraoxo-3-oxa-5,8,11,14-tetraazahexadecan-16-oate

: 1472004-41-3
2-[(2-({2-[(2-aminoacetyl)amino]acetyl}amino)-5-{bis[2-(diphenylphosphoryl)ethyl]amino}-5-oxopentanoyl)amino]acetic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 23 ℃; for 3h;
DOI:10.1055/s-0033-1339340

Reference yield:

: 1472004-37-7
C₂₇H₄₀N₄O₉

: 1472004-41-3
2-[(2-({2-[(2-aminoacetyl)amino]acetyl}amino)-5-{bis[2-(diphenylphosphoryl)ethyl]amino}-5-oxopentanoyl)amino]acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen; 5%-palladium/activated carbon / ethyl acetate / 48 h / 23 °C

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0.5 h / 23 °C

2.2: 16 h / 23 °C

3.1: oxygen / tetrahydrofuran / 3 h / 20 °C / UV-irradiation

4.1: trifluoroacetic acid / dichloromethane / 3 h / 23 °C

With 5%-palladium/activated carbon; hydrogen; oxygen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1055/s-0033-1339340

Reference yield:

: 1472004-38-8
12-{[(2-tert-butoxy-2-oxoethyl)amino]carbonyl}-2,2-dimethyl-4,7,10-trioxo-3-oxa-5,8,11-triazapentadecan-15-oic acid

: 1472004-41-3
2-[(2-({2-[(2-aminoacetyl)amino]acetyl}amino)-5-{bis[2-(diphenylphosphoryl)ethyl]amino}-5-oxopentanoyl)amino]acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0.5 h / 23 °C

1.2: 16 h / 23 °C

2.1: oxygen / tetrahydrofuran / 3 h / 20 °C / UV-irradiation

3.1: trifluoroacetic acid / dichloromethane / 3 h / 23 °C

With oxygen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1055/s-0033-1339340