(10bR)-6,10b-dihydro-8,9-dimethoxy-10b-methyl-2-<(R)-1-phenylethyl>-5H-imidazo<4,3-a>isoquinoline-1(2H),3(4H)-dione

Base Information

Chemical Name:(10bR)-6,10b-dihydro-8,9-dimethoxy-10b-methyl-2-<(R)-1-phenylethyl>-5H-imidazo<4,3-a>isoquinoline-1(2H),3(4H)-dione
CAS No.:145122-35-6
Molecular Formula:C₂₂H₂₄N₂O₄
Molecular Weight:380.444
Hs Code.:

Synonyms:(10bR)-6,10b-dihydro-8,9-dimethoxy-10b-methyl-2-<(R)-1-phenylethyl>-5H-imidazo<4,3-a>isoquinoline-1(2H),3(4H)-dione

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Chemical Property of (10bR)-6,10b-dihydro-8,9-dimethoxy-10b-methyl-2-<(R)-1-phenylethyl>-5H-imidazo<4,3-a>isoquinoline-1(2H),3(4H)-dione

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Technology Process of (10bR)-6,10b-dihydro-8,9-dimethoxy-10b-methyl-2-<(R)-1-phenylethyl>-5H-imidazo<4,3-a>isoquinoline-1(2H),3(4H)-dione

There total 4 articles about (10bR)-6,10b-dihydro-8,9-dimethoxy-10b-methyl-2-<(R)-1-phenylethyl>-5H-imidazo<4,3-a>isoquinoline-1(2H),3(4H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 186581-53-3,908094-01-9,334-88-3
diazomethane

: 110691-61-7
(1R)-1,2,3,4-tetrahydro-6-hydroxy-7-methoxy-1-methoxycarbonyl-1-methyl-2-<<(R)-1-phenylethyl>carbamoyl>isoquinoline

: 145122-35-6
(10bR)-6,10b-dihydro-8,9-dimethoxy-10b-methyl-2-<(R)-1-phenylethyl>-5H-imidazo<4,3-a>isoquinoline-1(2H),3(4H)-dione

Guidance literature:: In methanol; diethyl ether; at 23 ℃; for 16h;

Reference yield:

: 88598-26-9,31758-50-6
salsoline-1-carboxylic acid

: 145122-35-6
(10bR)-6,10b-dihydro-8,9-dimethoxy-10b-methyl-2-<(R)-1-phenylethyl>-5H-imidazo<4,3-a>isoquinoline-1(2H),3(4H)-dione

Guidance literature:: Multi-step reaction with 3 steps

1: 55 percent / SOCl₂ / 1.) reflux, 5 h, 2.) 20 deg C, overnight, 3.) reflux, 1.5 h

2: 38 percent / CHCl₃ / 1.) 0 deg C, 2h, 2.) to r.t.

3: 100 percent / methanol; diethyl ether / 16 h / 23 °C

With thionyl chloride; In methanol; diethyl ether; chloroform;

Reference yield:

: 645-33-0
3-hydroxy-4-methoxy-β-phenethylamine hydrochloride

: 145122-35-6
(10bR)-6,10b-dihydro-8,9-dimethoxy-10b-methyl-2-<(R)-1-phenylethyl>-5H-imidazo<4,3-a>isoquinoline-1(2H),3(4H)-dione

Guidance literature:: Multi-step reaction with 4 steps

1: 89 percent / aq. ammonia / 18 h / 32 °C / pH = 7 (adjusted with HCl)

2: 55 percent / SOCl₂ / 1.) reflux, 5 h, 2.) 20 deg C, overnight, 3.) reflux, 1.5 h

3: 38 percent / CHCl₃ / 1.) 0 deg C, 2h, 2.) to r.t.

4: 100 percent / methanol; diethyl ether / 16 h / 23 °C

With ammonium hydroxide; thionyl chloride; In methanol; diethyl ether; chloroform;