2-Fluoro-6-phenylpyridine

Base Information

• Chemical Name: 2-Fluoro-6-phenylpyridine
• CAS No.: 180606-17-1
• Molecular Formula: C11H8FN
• Molecular Weight: 173.19
• DSSTox Substance ID: DTXSID10376546
• Nikkaji Number: J3.329.591J
• Wikidata: Q82165440
• Mol file: 180606-17-1.mol

Synonyms:2-fluoro-6-phenylpyridine;180606-17-1;Pyridine, 2-fluoro-6-phenyl-;SCHEMBL4651412;DTXSID10376546;AXSUBWDOWSHTSC-UHFFFAOYSA-N;AKOS006292656;SB54967;CS-0336752;FT-0691680;A850109;J-509504

Chemical Property of 2-Fluoro-6-phenylpyridine

Chemical Property:

• Vapor Pressure: 0.0061mmHg at 25°C
• Refractive Index: 1.556
• Boiling Point: 281.3 °C at 760 mmHg
• Flash Point: 124 °C
• PSA: 12.89000
• Density: 1.138 g/cm³
• LogP: 2.88770
• Storage Temp.: 2-8°C
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 173.064077422
• Heavy Atom Count: 13
• Complexity: 154

Purity/Quality:

97% ^*data from raw suppliers

2-Fluoro-6-phenylpyridine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=NC(=CC=C2)F

Technology Process of 2-Fluoro-6-phenylpyridine

There total 10 articles about 2-Fluoro-6-phenylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-bromo-6-fluoropyridine (144100-07-2) + potassium phenyltrifluoborate → 2-fluoro-6-phenyl-pyridine (180606-17-1)

Guidance literature:

With 5%-palladium/activated carbon; oxygen; potassium carbonate; In ethanol; water; at 80 ℃; for 1.3h;

DOI:10.1016/j.cclet.2015.12.022

Reference yield: 87.0%

2-bromo-6-fluoropyridine (144100-07-2) + phenylboronic acid (98-80-6) → 2-fluoro-6-phenyl-pyridine (180606-17-1)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,2-dimethoxyethane; water; for 16h; Inert atmosphere;

Reference yield: 82.0%

bromobenzene (108-86-1,52753-63-6) + potassium 6-fluoropyridine-2-trifluoroborate → 2-fluoro-6-phenyl-pyridine (180606-17-1)

Guidance literature:

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; sodium carbonate; In ethanol; at 85 ℃; for 16h; Inert atmosphere;

DOI:10.1016/j.tet.2011.12.036

upstream raw materials:

2,6-difluoro pyridine

phenyllithium

bromobenzene

2-bromo-6-fluoropyridine

Downstream raw materials:

2-fluoro-6-phenyl-pyridine-3-carboxylic acid

N-(n-octyl)-6-phenylpyridin-2-amine

4-(6-phenylpyridin-2-yl)morpholine

6-phenyl-pyridine-2-carbonitrile