3- Benzyl -3-spiro[bicyclo[3.2.1]cyclooctane-8,2'-[1,3]Dioxane]

Base Information

• Chemical Name: 3- Benzyl -3-spiro[bicyclo[3.2.1]cyclooctane-8,2'-[1,3]Dioxane]
• CAS No.: 1019208-04-8
• Molecular Formula: C₁₆H₂₁NO₂
• Molecular Weight: 259.348
• Mol file: 1019208-04-8.mol

Synonyms:3'-benzylspiro[1,3-dioxolane-2,8'-3-azabicyclo[3.2.1]octane]

Chemical Property of 3- Benzyl -3-spiro[bicyclo[3.2.1]cyclooctane-8,2'-[1,3]Dioxane]

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

3-Benzyl-3-azaspiro[bicyclo[3.2.1]octane-8,2'-[1,3]dioxolane] 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3- Benzyl -3-spiro[bicyclo[3.2.1]cyclooctane-8,2'-[1,3]Dioxane]

There total 3 articles about 3- Benzyl -3-spiro[bicyclo[3.2.1]cyclooctane-8,2'-[1,3]Dioxane] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.4%

3-benzyl-1,5,3-dioxazepane (1019208-03-7) + cyclopentanone (120-92-3) → 3'-benzylspiro[1,3-dioxolane-2,8'-3-azabicyclo[3.2.1]octane] (1019208-04-8)

Guidance literature:

cyclopentanone; With dimethylsilicon dichloride; sodium iodide; In acetonitrile; at 0 ℃; for 0.666667h;

3-benzyl-1,5,3-dioxazepane; In acetonitrile; at 0 - 20 ℃; for 1.16667 - 2.66667h;

With sodium hydrogencarbonate; In water; acetonitrile; Product distribution / selectivity;

Reference yield:

3-benzyl-1,5,3-dioxazepane (1019208-03-7) + cyclopentanone (120-92-3) → 3'-benzylspiro[1,3-dioxolane-2,8'-3-azabicyclo[3.2.1]octane] (1019208-04-8) + 3-benzyl-3-aza-bicyclo[3.2.1]octan-8-one (83507-33-9)

Guidance literature:

With hydrogenchloride; water; at 0 - 20 ℃;

Reference yield:

benzylamine (100-46-9) → 3'-benzylspiro[1,3-dioxolane-2,8'-3-azabicyclo[3.2.1]octane] (1019208-04-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: toluene / 3 h / 110 °C / Dean-Stark

2.1: sodium iodide; chloro-trimethyl-silane / acetonitrile / 0.33 h / 0 °C / Inert atmosphere

2.2: 6 h / 0 - 40 °C / Inert atmosphere

With chloro-trimethyl-silane; sodium iodide; In toluene; acetonitrile;

upstream raw materials:

3-benzyl-1,5,3-dioxazepane

cyclopentanone

benzylamine

Downstream raw materials:

3-benzyl-3-aza-bicyclo[3.2.1]octan-8-one

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