(E)-{2-[2-(tert-butyldiphenyl-silanyloxy)-cyclobutylidene]-ethyl}-9H-purin-6-ylamine

Base Information

Chemical Name:(E)-{2-[2-(tert-butyldiphenyl-silanyloxy)-cyclobutylidene]-ethyl}-9H-purin-6-ylamine
CAS No.:859793-24-1
Molecular Formula:C₂₇H₃₁N₅OSi
Molecular Weight:469.662
Hs Code.:

Synonyms:(E)-{2-[2-(tert-butyldiphenyl-silanyloxy)-cyclobutylidene]-ethyl}-9H-purin-6-ylamine

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Chemical Property of (E)-{2-[2-(tert-butyldiphenyl-silanyloxy)-cyclobutylidene]-ethyl}-9H-purin-6-ylamine

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Technology Process of (E)-{2-[2-(tert-butyldiphenyl-silanyloxy)-cyclobutylidene]-ethyl}-9H-purin-6-ylamine

There total 4 articles about (E)-{2-[2-(tert-butyldiphenyl-silanyloxy)-cyclobutylidene]-ethyl}-9H-purin-6-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 859793-21-8
(E)-2-{(tert-butyldiphenylsilyl)oxycyclobutylidene}ethanol

: 66224-66-6,66224-67-7,66224-68-8,66224-69-9,134434-48-3,134434-49-4,134454-76-5,134461-75-9
adenine

: 859793-24-1
(E)-{2-[2-(tert-butyldiphenyl-silanyloxy)-cyclobutylidene]-ethyl}-9H-purin-6-ylamine

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 168000h;
DOI:10.1016/j.tet.2005.04.023

Reference yield:

: 859793-17-2
2-{(tert-butyldiphenylsilyl)oxycyclobutanone}

: 859793-24-1
(E)-{2-[2-(tert-butyldiphenyl-silanyloxy)-cyclobutylidene]-ethyl}-9H-purin-6-ylamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium diisopropylamide / tetrahydrofuran; hexane / -78 °C

1.2: tetrahydrofuran; hexane / 1 h

2.1: 87 percent / DIBALH / CH₂Cl₂; toluene / 2 h / -60 °C

3.1: 46 percent / triphenylphosphine; DIAD / tetrahydrofuran / 168000 h / 20 °C

With di-isopropyl azodicarboxylate; diisobutylaluminium hydride; triphenylphosphine; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane; toluene; 1.1: Peterson reaction / 3.1: Mitsunobu reaction;
DOI:10.1016/j.tet.2005.04.023

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 859793-24-1
(E)-{2-[2-(tert-butyldiphenyl-silanyloxy)-cyclobutylidene]-ethyl}-9H-purin-6-ylamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: 90 percent / imidazole / dimethylformamide / 20 h / 20 °C

2.1: lithium diisopropylamide / tetrahydrofuran; hexane / -78 °C

2.2: tetrahydrofuran; hexane / 1 h

3.1: 87 percent / DIBALH / CH₂Cl₂; toluene / 2 h / -60 °C

4.1: 46 percent / triphenylphosphine; DIAD / tetrahydrofuran / 168000 h / 20 °C

With 1H-imidazole; di-isopropyl azodicarboxylate; diisobutylaluminium hydride; triphenylphosphine; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; toluene; 2.1: Peterson reaction / 4.1: Mitsunobu reaction;
DOI:10.1016/j.tet.2005.04.023