(5R,9R,10R)-(+)-drim-7-en-11-ol

Base Information

• Chemical Name: (5R,9R,10R)-(+)-drim-7-en-11-ol
• CAS No.: 186366-21-2
• Molecular Formula: C₁₅H₂₆O
• Molecular Weight: 222.371
• Mol file: 186366-21-2.mol

Synonyms:(5R,9R,10R)-(+)-drim-7-en-11-ol

Chemical Property of (5R,9R,10R)-(+)-drim-7-en-11-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (5R,9R,10R)-(+)-drim-7-en-11-ol

There total 1 articles about (5R,9R,10R)-(+)-drim-7-en-11-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(+/-)-drim-7-en-11-ol acetate → (-)-drimenol (468-68-8) + [(1S,4a5,8a5)-2,5,5,8a-tetramethyl-1,4,4a,5,6,7,8,8a-octahydronaphthalen-1-yl]methyl acetate (50490-38-5,125354-06-5,40266-93-1) + (5R,9R,10R)-(+)-drim-7-en-11-ol (186366-21-2) + (5R,9R,10R)-drim-7-en-11-ol acetate

Guidance literature:

With hog pancreas lipase; In phosphate buffer; at 20 ℃; for 22h; pH=6.5; Title compound not separated from byproducts;

DOI:10.1070/mc2002v012n02abeh001566

Reference yield:

(5R,9R,10R)-(+)-drim-7-en-11-ol (186366-21-2) → (+)-isozonarol (39707-55-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 97 percent / pyridinium chlorochromate / CH₂Cl₂ / 0.5 h / 20 °C

2: 80 percent / sec-BuLi / tetrahydrofuran; cyclohexane / 0.25 h / 20 °C

3: 98 percent / Li / liquid ammonia; tetrahydrofuran / 0.25 h / -78 °C

4: 84 percent / oxalic acid / methanol; ethyl acetate; H₂O / 5 h / 40 °C

With sec.-butyllithium; oxalic acid; lithium; pyridinium chlorochromate; In tetrahydrofuran; methanol; dichloromethane; cyclohexane; ammonia; water; ethyl acetate;

DOI:10.1016/S0040-4020(02)00346-0

Reference yield:

(5R,9R,10R)-(+)-drim-7-en-11-ol (186366-21-2) → isozonarone (39707-59-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 97 percent / pyridinium chlorochromate / CH₂Cl₂ / 0.5 h / 20 °C

2: 80 percent / sec-BuLi / tetrahydrofuran; cyclohexane / 0.25 h / 20 °C

3: 98 percent / Li / liquid ammonia; tetrahydrofuran / 0.25 h / -78 °C

4: 84 percent / oxalic acid / methanol; ethyl acetate; H₂O / 5 h / 40 °C

5: 91 percent / ceric ammonium nitrate / dimethylformamide; acetonitrile; H₂O / 0.5 h

With ammonium cerium(IV) nitrate; sec.-butyllithium; oxalic acid; lithium; pyridinium chlorochromate; In tetrahydrofuran; methanol; dichloromethane; cyclohexane; ammonia; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/S0040-4020(02)00346-0

Downstream raw materials:

(+)-isozonarol

isozonarone

C₃₁H₄₆O₄

(11R,S)-11-(2',5'-di(tetrahydropyran-2-yloxy)-1'-phenyl)drim-7-en-11-ol