3-(1-hydroxy-3-phenyl-propyl)-5-(methanesulphonyl-methyl-amino)-benzoic acid methyl ester

Base Information

Chemical Name:3-(1-hydroxy-3-phenyl-propyl)-5-(methanesulphonyl-methyl-amino)-benzoic acid methyl ester
CAS No.:1067649-07-3
Molecular Formula:C₁₉H₂₃NO₅S
Molecular Weight:377.461
Hs Code.:

Synonyms:3-(1-hydroxy-3-phenyl-propyl)-5-(methanesulphonyl-methyl-amino)-benzoic acid methyl ester

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Chemical Property of 3-(1-hydroxy-3-phenyl-propyl)-5-(methanesulphonyl-methyl-amino)-benzoic acid methyl ester

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Technology Process of 3-(1-hydroxy-3-phenyl-propyl)-5-(methanesulphonyl-methyl-amino)-benzoic acid methyl ester

There total 1 articles about 3-(1-hydroxy-3-phenyl-propyl)-5-(methanesulphonyl-methyl-amino)-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 695216-60-5
3-formyl-5-[methanesulphonyl(methyl)amino]benzoic acid methyl ester

: 90878-19-6
phenethylmagnesium chloride

: 1067649-07-3
3-(1-hydroxy-3-phenyl-propyl)-5-(methanesulphonyl-methyl-amino)-benzoic acid methyl ester

Guidance literature:: 3-formyl-5-[methanesulphonyl(methyl)amino]benzoic acid methyl ester; phenethylmagnesium chloride; In tetrahydrofuran; diethyl ether; at -78 ℃; for 6h;

With water; ammonium chloride; In tetrahydrofuran; diethyl ether; at -78 - 20 ℃;

Reference yield: 93.0%

: 1067649-07-3
3-(1-hydroxy-3-phenyl-propyl)-5-(methanesulphonyl-methyl-amino)-benzoic acid methyl ester

: 6482-24-2
2-Bromoethyl methyl ether

: 1067649-09-5
3-(methanesulphonyl-methyl-amino)-5-[1-(2-methoxy-ethoxy)-3-phenyl-propyl]-benzoic acid

Guidance literature:: 3-(1-hydroxy-3-phenyl-propyl)-5-(methanesulphonyl-methyl-amino)-benzoic acid methyl ester; With sodium hydride; In N,N-dimethyl-formamide; at -15 - -10 ℃; for 0.5h;

2-Bromoethyl methyl ether; In N,N-dimethyl-formamide; at -15 - -10 ℃; for 3h;

With hydrogenchloride; methanol; water; In N,N-dimethyl-formamide;

Reference yield:

: 1067649-07-3
3-(1-hydroxy-3-phenyl-propyl)-5-(methanesulphonyl-methyl-amino)-benzoic acid methyl ester

: N-[(1S,2S,4S)-4-((S)-1-benzylcarbamoyl-2-methyl-propylcarbamoyl)-1-benzyloxymethyl-2-hydroxy-5-methyl-hexyl]-3-(methanesulphonyl-methyl-amino)-5-[(R)-1-(2-methoxy-ethoxy)-3-phenyl-propyl]-benzamide

: N-[(1S,2S,4S)-4-((S)-1-benzylcarbamoyl-2-methyl-propylcarbamoyl)-1-benzyloxymethyl-2-hydroxy-5-methyl-hexyl]-3-(methanesulphonyl-methyl-amino)-5-[(S)-1-(2-methoxy-ethoxy)-3-phenyl-propyl]-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / -15 - -10 °C

1.2: 3 h

2.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide

With sodium hydride; N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide;