12-[2-(4-Hydroxymethyl-2-[D₃]methoxyphenoxy)-[D₄]ethoxy]-3,8,13-trimethoxy-10,15-dihydro-5H-tribenzo[a,d,g]cyclononene-2,7-diol

Base Information

• Chemical Name: 12-[2-(4-Hydroxymethyl-2-[D₃]methoxyphenoxy)-[D₄]ethoxy]-3,8,13-trimethoxy-10,15-dihydro-5H-tribenzo[a,d,g]cyclononene-2,7-diol
• CAS No.: 347894-50-2
• Molecular Formula: C₃₄H₃₆O₉
• Molecular Weight: 595.599

Synonyms:12-[2-(4-Hydroxymethyl-2-[D₃]methoxyphenoxy)-[D₄]ethoxy]-3,8,13-trimethoxy-10,15-dihydro-5H-tribenzo[a,d,g]cyclononene-2,7-diol

Chemical Property of 12-[2-(4-Hydroxymethyl-2-[D₃]methoxyphenoxy)-[D₄]ethoxy]-3,8,13-trimethoxy-10,15-dihydro-5H-tribenzo[a,d,g]cyclononene-2,7-diol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 12-[2-(4-Hydroxymethyl-2-[D₃]methoxyphenoxy)-[D₄]ethoxy]-3,8,13-trimethoxy-10,15-dihydro-5H-tribenzo[a,d,g]cyclononene-2,7-diol

There total 9 articles about 12-[2-(4-Hydroxymethyl-2-[D₃]methoxyphenoxy)-[D₄]ethoxy]-3,8,13-trimethoxy-10,15-dihydro-5H-tribenzo[a,d,g]cyclononene-2,7-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

cyclotriguaiacyclene (81370-49-2,68198-62-9,75322-24-6,68182-93-4) + [4-(2-[D4]Iodoethoxy)-3-[D3]methoxyphenyl]methanol (347894-44-4) → 12-[2-(4-Hydroxymethyl-2-[D3]methoxyphenoxy)-[D4]ethoxy]-3,8,13-trimethoxy-10,15-dihydro-5H-tribenzo[a,d,g]cyclononene-2,7-diol (347894-50-2)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 18h;

DOI:10.1002/1521-3765(20010401)7:7<1561::AID-CHEM1561>3.0.CO;2-9

Reference yield:

3-hydroxy-4-(2-propenyloxy)benzaldehyde (79822-65-4) → 12-[2-(4-Hydroxymethyl-2-[D3]methoxyphenoxy)-[D4]ethoxy]-3,8,13-trimethoxy-10,15-dihydro-5H-tribenzo[a,d,g]cyclononene-2,7-diol (347894-50-2)

Guidance literature:

Multi-step reaction with 8 steps

1: 94 percent / K₂CO₃ / dimethylformamide / 80 °C

2: 91 percent / NaBH₄ / methanol / 20 °C

3: 93 percent / PPTS / CH₂Cl₂; tetrahydrofuran / 20 °C

4: 77 percent / PPh₃; NHEt₂; Pd(OAc)2 / tetrahydrofuran; H₂O / 3 h / 80 °C

5: 56 percent / K₂CO₃ / acetone / 80 °C

6: 97 percent / NaI / acetone / Heating

7: 97 percent / PPTS / ethanol / 5 h / 55 °C

8: 20 percent / Cs₂CO₃ / dimethylformamide / 18 h / 80 °C

With palladium diacetate; sodium tetrahydroborate; pyridinium p-toluenesulfonate; potassium carbonate; caesium carbonate; diethylamine; triphenylphosphine; sodium iodide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone;

DOI:10.1002/1521-3765(20010401)7:7<1561::AID-CHEM1561>3.0.CO;2-9

Reference yield:

3,4-dihydroxybenzaldehyde (139-85-5) → 12-[2-(4-Hydroxymethyl-2-[D3]methoxyphenoxy)-[D4]ethoxy]-3,8,13-trimethoxy-10,15-dihydro-5H-tribenzo[a,d,g]cyclononene-2,7-diol (347894-50-2)

Guidance literature:

Multi-step reaction with 9 steps

1: 56 percent / Li₂CO₃ / dimethylformamide / 55 °C

2: 94 percent / K₂CO₃ / dimethylformamide / 80 °C

3: 91 percent / NaBH₄ / methanol / 20 °C

4: 93 percent / PPTS / CH₂Cl₂; tetrahydrofuran / 20 °C

5: 77 percent / PPh₃; NHEt₂; Pd(OAc)2 / tetrahydrofuran; H₂O / 3 h / 80 °C

6: 56 percent / K₂CO₃ / acetone / 80 °C

7: 97 percent / NaI / acetone / Heating

8: 97 percent / PPTS / ethanol / 5 h / 55 °C

9: 20 percent / Cs₂CO₃ / dimethylformamide / 18 h / 80 °C

With palladium diacetate; sodium tetrahydroborate; pyridinium p-toluenesulfonate; lithium carbonate; potassium carbonate; caesium carbonate; diethylamine; triphenylphosphine; sodium iodide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone;

DOI:10.1002/1521-3765(20010401)7:7<1561::AID-CHEM1561>3.0.CO;2-9

upstream raw materials:

cyclotriguaiacyclene

[4-(2-[D₄]Iodoethoxy)-3-[D₃]methoxyphenyl]methanol

3-hydroxy-4-(2-propenyloxy)benzaldehyde

3,4-dihydroxybenzaldehyde

Downstream raw materials:

{3-[D₃]Methoxy-4-[2-(3,8,13-trimethoxy-7,12-bis{2-[2-methoxy-4-(tetrahydropyran-2-yloxymethyl)phenoxy]-[D₄]ethoxy}-10,15-dihydro-5H-tribenzo[a,d,g]cyclononen-2-yloxy)-[D₄]ethoxy]phenyl}methanol

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 347894-50-2 12-[2-(4-Hydroxymethyl-2-[D₃]methoxyphenoxy)-[D₄]ethoxy]-3,8,13-trimethoxy-10,15-dihydro-5H-tribenzo[a,d,g]cyclononene-2,7-diol

Send

Send

Metric Ton KG G Pound L ML

Send

Send