-O<<(tert-butyloxy)carbonyl>-L-valyl>-D-seryl>-N-methyl-L-alanine 2,2,2-Trichloroethyl Ester

Base Information

• Chemical Name: -O<<(tert-butyloxy)carbonyl>-L-valyl>-D-seryl>-N-methyl-L-alanine 2,2,2-Trichloroethyl Ester
• CAS No.: 78166-93-5
• Molecular Formula: C₂₇H₃₈Cl₃N₃O₉
• Molecular Weight: 654.972
• Mol file: 78166-93-5.mol

Synonyms:-O<<(tert-butyloxy)carbonyl>-L-valyl>-D-seryl>-N-methyl-L-alanine 2,2,2-Trichloroethyl Ester

Chemical Property of -O<<(tert-butyloxy)carbonyl>-L-valyl>-D-seryl>-N-methyl-L-alanine 2,2,2-Trichloroethyl Ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of -O<<(tert-butyloxy)carbonyl>-L-valyl>-D-seryl>-N-methyl-L-alanine 2,2,2-Trichloroethyl Ester

There total 3 articles about -O<<(tert-butyloxy)carbonyl>-L-valyl>-D-seryl>-N-methyl-L-alanine 2,2,2-Trichloroethyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.5%

t-Boc-L-valine (13734-41-3) + -D-seryl>-N-methyl-L-alanine 2,2,2-Trichloroethyl Ester (78166-92-4) → -O<<(tert-butyloxy)carbonyl>-L-valyl>-D-seryl>-N-methyl-L-alanine 2,2,2-Trichloroethyl Ester (78166-93-5)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; In dichloromethane; 1.) 0 deg C, 3 h, 2.) room temperature, overnight;

DOI:10.1021/jo00330a010

Reference yield:

N-Methyl-L-alanine 2,2,2-Trichloroethyl Ester Hydrobromide (78166-91-3) → -O<<(tert-butyloxy)carbonyl>-L-valyl>-D-seryl>-N-methyl-L-alanine 2,2,2-Trichloroethyl Ester (78166-93-5)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / CH₂Cl₂ / 0.08 h / 0 °C

2: 88 percent / Et₃N / CH₂Cl₂ / 60 h / Ambient temperature

3: 87.5 percent / 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / 4-(dimethylamino)pyridine / CH₂Cl₂ / 1.) 0 deg C, 3 h, 2.) room temperature, overnight

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; dmap; triethylamine; In dichloromethane;

DOI:10.1021/jo00330a010

Reference yield:

N-Methyl-L-alanine 2,2,2-Trichloroethyl Ester (78166-90-2) → -O<<(tert-butyloxy)carbonyl>-L-valyl>-D-seryl>-N-methyl-L-alanine 2,2,2-Trichloroethyl Ester (78166-93-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / Et₃N / CH₂Cl₂ / 60 h / Ambient temperature

2: 87.5 percent / 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / 4-(dimethylamino)pyridine / CH₂Cl₂ / 1.) 0 deg C, 3 h, 2.) room temperature, overnight

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; triethylamine; In dichloromethane;

DOI:10.1021/jo00330a010

upstream raw materials:

t-Boc-L-valine

-D-seryl>-N-methyl-L-alanine 2,2,2-Trichloroethyl Ester

N-Methyl-L-alanine 2,2,2-Trichloroethyl Ester Hydrobromide

N-Methyl-L-alanine 2,2,2-Trichloroethyl Ester

Downstream raw materials:

-O-<-L-valyl>-D-seryl>-N-methyl-L-alanine 2,2,2-Trichloroethyl Ester

-O-<<(tert-butyloxy)carbonyl>-S-(acetamidomethyl)-L-cysteinyl-L-valyl>-D-seryl>-N-methyl-L-alanine 2,2,2-Trichloroethyl Ester