C₁₇H₁₉ClN₄O₃

Base Information

• Chemical Name: C₁₇H₁₉ClN₄O₃
• CAS No.: 1418120-66-7
• Molecular Formula: C₁₇H₁₉ClN₄O₃
• Molecular Weight: 362.816
• Mol file: 1418120-66-7.mol

Synonyms:C₁₇H₁₉ClN₄O₃

Chemical Property of C₁₇H₁₉ClN₄O₃

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₇H₁₉ClN₄O₃

There total 6 articles about C₁₇H₁₉ClN₄O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C21H27ClN4O3 (1448189-41-0) → C17H19ClN4O3 (1418120-66-7)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 12h;

DOI:10.1002/anie.201206231

Reference yield:

(2S,4R)-(9H-fluoren-9-yl)methyl 4-(tert-butoxy)-2-((4-chlorobenzyl)carbamoyl)pyrrolidine-1-carboxylate (1448189-39-6) → C17H19ClN4O3 (1418120-66-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 2,2',2''-triaminotriethylamine / dichloromethane / 14 h / 4 - 20 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 14.5 h / 20 °C

3: trifluoroacetic acid / dichloromethane / 12 h / 20 °C

With 2,2',2''-triaminotriethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane;

DOI:10.1002/anie.201206231

Reference yield:

(2S,4R)-4-(tert-butoxy)-N-(4-chlorobenzyl)pyrrolidine-2-carboxamide (1448189-40-9) → C17H19ClN4O3 (1418120-66-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 14.5 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 12 h / 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane;

DOI:10.1002/anie.201206231

upstream raw materials:

(2S,4R)-4-tert-butoxy-1-(9H-fluoren-9-ylmethoxycarbonyl)pyrrolidine-2-carboxylic acid

4-chlorobenzylamine

(2S,4R)-(9H-fluoren-9-yl)methyl 4-(tert-butoxy)-2-((4-chlorobenzyl)carbamoyl)pyrrolidine-1-carboxylate

(2S,4R)-4-(tert-butoxy)-N-(4-chlorobenzyl)pyrrolidine-2-carboxamide