methyl 4-(4-(4-cyanophenyl)-2,5-dioxo-1-(3-(trifluoromethyl)phenyl)-6,7-dihydro-1H-cyclopenta[d]pyrimidin-3(2H,4H,5H)-ylsulfonyl)butanoate

Base Information

Chemical Name:methyl 4-(4-(4-cyanophenyl)-2,5-dioxo-1-(3-(trifluoromethyl)phenyl)-6,7-dihydro-1H-cyclopenta[d]pyrimidin-3(2H,4H,5H)-ylsulfonyl)butanoate
CAS No.:1621271-41-7
Molecular Formula:C₂₆H₂₂F₃N₃O₆S
Molecular Weight:561.538
Hs Code.:

Synonyms:methyl 4-(4-(4-cyanophenyl)-2,5-dioxo-1-(3-(trifluoromethyl)phenyl)-6,7-dihydro-1H-cyclopenta[d]pyrimidin-3(2H,4H,5H)-ylsulfonyl)butanoate

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Chemical Property of methyl 4-(4-(4-cyanophenyl)-2,5-dioxo-1-(3-(trifluoromethyl)phenyl)-6,7-dihydro-1H-cyclopenta[d]pyrimidin-3(2H,4H,5H)-ylsulfonyl)butanoate

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Technology Process of methyl 4-(4-(4-cyanophenyl)-2,5-dioxo-1-(3-(trifluoromethyl)phenyl)-6,7-dihydro-1H-cyclopenta[d]pyrimidin-3(2H,4H,5H)-ylsulfonyl)butanoate

There total 10 articles about methyl 4-(4-(4-cyanophenyl)-2,5-dioxo-1-(3-(trifluoromethyl)phenyl)-6,7-dihydro-1H-cyclopenta[d]pyrimidin-3(2H,4H,5H)-ylsulfonyl)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1621269-89-3
4-(2,5-dioxo-1-(3-(trifluoromethyl)phenyl)-2,3,4,5,6,7-hexahydro-1H-cyclopenta[d]-pyrimidin-4-yl)benzonitrile

: 81926-28-5
methyl 4-(4-chlorosulfonyl)butyrate

: 1621271-41-7
methyl 4-(4-(4-cyanophenyl)-2,5-dioxo-1-(3-(trifluoromethyl)phenyl)-6,7-dihydro-1H-cyclopenta[d]pyrimidin-3(2H,4H,5H)-ylsulfonyl)butanoate

Guidance literature:: 4-(2,5-dioxo-1-(3-(trifluoromethyl)phenyl)-2,3,4,5,6,7-hexahydro-1H-cyclopenta[d]-pyrimidin-4-yl)benzonitrile; With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 0.0833333h;

methyl 4-(4-chlorosulfonyl)butyrate; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil; at 50 ℃;

Reference yield:

: 3-[[3-(trifluoromethyl)phenyl]amino]-2-cyclopenten-1-one

: 1621271-41-7
methyl 4-(4-(4-cyanophenyl)-2,5-dioxo-1-(3-(trifluoromethyl)phenyl)-6,7-dihydro-1H-cyclopenta[d]pyrimidin-3(2H,4H,5H)-ylsulfonyl)butanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: dichloromethane / 20 °C / Reflux

2.1: sodium hydride / mineral oil; tetrahydrofuran; N,N-dimethyl-formamide / 0.08 h / 20 °C

2.2: 50 °C

With sodium hydride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1621272-80-7
diethyl (4-cyanophenyl)methylenedicarbamate

: 1621271-41-7
methyl 4-(4-(4-cyanophenyl)-2,5-dioxo-1-(3-(trifluoromethyl)phenyl)-6,7-dihydro-1H-cyclopenta[d]pyrimidin-3(2H,4H,5H)-ylsulfonyl)butanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: phosphorus pentachloride / benzene / 2 h / Reflux

2.1: dichloromethane / 20 °C / Reflux

3.1: sodium hydride / mineral oil; tetrahydrofuran; N,N-dimethyl-formamide / 0.08 h / 20 °C

3.2: 50 °C

With phosphorus pentachloride; sodium hydride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; mineral oil; benzene;