Oxazole, 2-(4-ethoxyphenyl)-4,5-dihydro-4,4-dimethyl- (9CI)

Base Information

Chemical Name:Oxazole, 2-(4-ethoxyphenyl)-4,5-dihydro-4,4-dimethyl- (9CI)
CAS No.:180303-26-8
Molecular Formula:C₁₃H₁₇NO₂
Molecular Weight:219.283
Hs Code.:
Mol file:180303-26-8.mol

Synonyms:Oxazole, 2-(4-ethoxyphenyl)-4,5-dihydro-4,4-dimethyl- (9CI)

Suppliers and Price of Oxazole, 2-(4-ethoxyphenyl)-4,5-dihydro-4,4-dimethyl- (9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Oxazole, 2-(4-ethoxyphenyl)-4,5-dihydro-4,4-dimethyl- (9CI)

Chemical Property:

PSA：30.82000
LogP:2.07630

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Oxazole, 2-(4-ethoxyphenyl)-4,5-dihydro-4,4-dimethyl- (9CI)

There total 1 articles about Oxazole, 2-(4-ethoxyphenyl)-4,5-dihydro-4,4-dimethyl- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 180303-26-8
2-(4-ethoxy-phenyl)-4,4-dimethyl-4,5-dihydro-oxazole

Guidance literature:: With pyridine;
DOI:10.1021/ja01119a033

Reference yield:

: 180303-26-8
2-(4-ethoxy-phenyl)-4,4-dimethyl-4,5-dihydro-oxazole

: 2-((1S,3R)-3-Benzo[1,3]dioxol-5-yl-6-ethoxy-2,3-dihydro-1H-isoindol-1-yl)-5-methoxy-phenol

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) n-BuLi, 3.) aq. HCl / 1.) THF, -78 -> 0 deg C, 2.) THF, -78 deg C, 3.) THF, -78 deg C-> RT

2: tetrahydrofuran / 0 °C

3: pyridinium chlorochromate / CH₂Cl₂ / Ambient temperature

4: 1.) NH₄OAc, Na, 2.) Zn-Cu, AcOH / 1.) EtOH, 2.) RT

5: H₂ / Pd/C / ethyl acetate / Ambient temperature

With hydrogenchloride; n-butyllithium; ammonium acetate; hydrogen; sodium; copper; acetic acid; pyridinium chlorochromate; zinc; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1016/0040-4039(96)01018-0

Reference yield:

: 180303-26-8
2-(4-ethoxy-phenyl)-4,4-dimethyl-4,5-dihydro-oxazole

: [2-((1S,3R)-3-Benzo[1,3]dioxol-5-yl-6-ethoxy-2,3-dihydro-1H-isoindol-1-yl)-5-methoxy-phenoxy]-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) n-BuLi, 3.) aq. HCl / 1.) THF, -78 -> 0 deg C, 2.) THF, -78 deg C, 3.) THF, -78 deg C-> RT

2: tetrahydrofuran / 0 °C

3: pyridinium chlorochromate / CH₂Cl₂ / Ambient temperature

4: 1.) NH₄OAc, Na, 2.) Zn-Cu, AcOH / 1.) EtOH, 2.) RT

5: H₂ / Pd/C / ethyl acetate / Ambient temperature

6: NaH / tetrahydrofuran / Ambient temperature

With hydrogenchloride; n-butyllithium; ammonium acetate; hydrogen; sodium; copper; sodium hydride; acetic acid; pyridinium chlorochromate; zinc; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1016/0040-4039(96)01018-0