N-(benzyloxycarbonyl)aminomethylphosphonic acid

Base Information

• Chemical Name: N-(benzyloxycarbonyl)aminomethylphosphonic acid
• CAS No.: 55601-40-6
• Molecular Formula: C₉H₁₂NO₅P
• Molecular Weight: 245.172
• Mol file: 55601-40-6.mol

Synonyms:N-(benzyloxycarbonyl)aminomethylphosphonic acid

Chemical Property of N-(benzyloxycarbonyl)aminomethylphosphonic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of N-(benzyloxycarbonyl)aminomethylphosphonic acid

There total 5 articles about N-(benzyloxycarbonyl)aminomethylphosphonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

N-benzyloxycarbonylaminomethyl-H-phosphinic acid (131066-43-8) → N-(benzyloxycarbonyl)aminomethylphosphonic acid (55601-40-6)

Guidance literature:

With iodine; dimethyl sulfoxide; In tetrahydrofuran; at 60 ℃; for 5h; Inert atmosphere;

Reference yield:

N-<<<(benzyloxycarbonyl)amino>methyl>methoxyphosphinyl>-L-phenylalanine, dilithium salt (76228-61-0) → Phenylalanine (150-30-1,25191-15-5,658-69-5,67675-33-6) + N-(benzyloxycarbonyl)aminomethylphosphonic acid (55601-40-6)

Guidance literature:

With hydrogenchloride; In water; at 21 ℃; for 0.166667h; Product distribution; hydrolytic stability (half-life) at various pH; the presence of carboxypeptidase A does not effect the rate of hydrolysis;

DOI:10.1021/ja00393a026

Reference yield:

N,N'-dibenzylethylenediammonium bis[benzoyl N-(benzyloxycarbonyl)aminomethylphosphonate] → N-(benzyloxycarbonyl)aminomethylphosphonic acid (55601-40-6) + benzoic acid (65-85-0,8013-63-6)

Guidance literature:

With MOPS buffer; water; at 25 ℃; pH=7.5; Kinetics;

DOI:10.1006/bioo.2001.1218

upstream raw materials:

Aminomethylphosphonic acid

benzyl chloroformate

N-<<<(benzyloxycarbonyl)amino>methyl>methoxyphosphinyl>-L-phenylalanine, dilithium salt

N-benzyloxycarbonylaminomethyl-H-phosphinic acid

Downstream raw materials:

N-benzyloxycarbonylaminomethanephosphonic acid 2-cyanoethyl monoester

methyl <(N-carbobenzoxyamino)methyl>phosphonic acid

(Benzyloxycarbonylamino-methyl)-phosphonic acid 2-cyano-ethyl ester methyl ester

benzyl α-amino(diethylphosphono)acetate