(R)-N-(2-aminoethyl)-4-(8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-ylamino)-3-methoxybenzamide

Base Information

• Chemical Name: (R)-N-(2-aminoethyl)-4-(8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-ylamino)-3-methoxybenzamide
• CAS No.: 1344728-02-4
• Molecular Formula: C₂₄H₃₃N₇O₃
• Molecular Weight: 467.571
• Mol file: 1344728-02-4.mol

Synonyms:(R)-N-(2-aminoethyl)-4-(8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-ylamino)-3-methoxybenzamide

Chemical Property of (R)-N-(2-aminoethyl)-4-(8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-ylamino)-3-methoxybenzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-N-(2-aminoethyl)-4-(8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-ylamino)-3-methoxybenzamide

There total 5 articles about (R)-N-(2-aminoethyl)-4-(8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-ylamino)-3-methoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

(R)-4-((8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl)amino)-3-methoxybenzoic acid (755039-56-6) + ethylenediamine (107-15-3,85404-18-8) → (R)-N-(2-aminoethyl)-4-(8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-ylamino)-3-methoxybenzamide (1344728-02-4)

Guidance literature:

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; diisopropylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1002/anie.201103273

Reference yield:

(R)-2-chloro-8-cyclopentyl-7-ethyl-7,8-dihydropteridin-6(5H)-one (755039-54-4) → (R)-N-(2-aminoethyl)-4-(8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-ylamino)-3-methoxybenzamide (1344728-02-4)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydride / ISOPROPYLAMIDE; mineral oil / -10 - 20 °C / Inert atmosphere

2: hydrogenchloride / ethanol; water / 48 h / Inert atmosphere; Reflux

3: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; diisopropylamine / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; sodium hydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; diisopropylamine; In ethanol; ISOPROPYLAMIDE; water; N,N-dimethyl-formamide; mineral oil;

DOI:10.1002/anie.201103273

Reference yield:

(R)-2-chloro-8-cyclopentyl-7-ethyl-5-methyl-7,8-dihydropteridin-6(5H)-one (755039-55-5) → (R)-N-(2-aminoethyl)-4-(8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-ylamino)-3-methoxybenzamide (1344728-02-4)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / ethanol; water / 48 h / Inert atmosphere; Reflux

2: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; diisopropylamine / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; diisopropylamine; In ethanol; water; N,N-dimethyl-formamide;

DOI:10.1002/anie.201103273

upstream raw materials:

(R)-methyl 2-((2-chloro-5-nitropyrimidin-4-yl)(cyclopentyl)-amino)butanoate

(R)-2-chloro-8-cyclopentyl-7-ethyl-7,8-dihydropteridin-6(5H)-one

(R)-2-chloro-8-cyclopentyl-7-ethyl-5-methyl-7,8-dihydropteridin-6(5H)-one

(R)-4-((8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl)amino)-3-methoxybenzoic acid