elansolid B₁

Base Information

Chemical Name:elansolid B₁
CAS No.:1185198-94-0
Molecular Formula:C₃₇H₅₀O₇
Molecular Weight:606.8
Hs Code.:

Synonyms:elansolid B₁

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of elansolid B₁

Chemical Property:

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Technology Process of elansolid B₁

There total 28 articles about elansolid B₁ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1531627-42-5
C₃₉H₅₄O₇

: 1185198-94-0
elansolid B₁

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 5h;
DOI:10.1021/ol403441c

Reference yield:

: 1309113-21-0
(R,E)-(2-{5-[(tert-butyldimethylsilyl)oxy]-2,2-dimethylpent-3-en-1-yl}oxiran-2-yl)methanol

: 1185198-94-0
elansolid B₁

Guidance literature:: Multi-step reaction with 14 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h

2.1: PPTA / dichloromethane / 2 h / 20 °C

2.2: -78 - 20 °C

3.1: dmap; sodium hydrogencarbonate / dichloromethane / 3 h / 0 °C

4.1: potassium hexamethylsilazane / tetrahydrofuran / 1 h / -78 °C

4.2: -78 - 20 °C

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

6.1: NMO; tetrapropylammonium perruthennate / dichloromethane / 3 h / -30 °C / Molecular sieve

6.2: 0.42 h / -90 - -70 °C

7.1: tetrapropylammonium perruthennate; magnesium bromide ethyl etherate / dichloromethane / 3 h / 0 °C

8.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 0.83 h / 0 °C / pH 7

9.1: lithium aluminium tetrahydride / tetrahydrofuran / 65 h / -70 °C

10.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.25 h

11.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / 120 h / Darkness

12.1: camphor-10-sulfonic acid / acetone / 96 h

13.1: Zn-Ag couple / deuteromethanol / 5 h / Darkness

14.1: lithium hydroxide / methanol; tetrahydrofuran / 5 h / 20 °C

With dmap; copper(l) iodide; lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrapropylammonium perruthennate; NMO; camphor-10-sulfonic acid; tetrabutyl ammonium fluoride; potassium hexamethylsilazane; sodium hydrogencarbonate; magnesium bromide ethyl etherate; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; deuteromethanol; acetone;
DOI:10.1021/ol403441c

Reference yield:

: 1309113-14-1
(E)-tert-butyl[(6-{[(4-methoxybenzyl)oxy]methyl}-4,4-dimethylhepta-2,6-dien-1-yl)oxy]dimethylsilane

: 1185198-94-0
elansolid B₁

Guidance literature:: Multi-step reaction with 16 steps

1.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 20 °C

2.1: titanium(IV) isopropylate; tert.-butylhydroperoxide / dichloromethane / 20 h / -25 °C

2.2: Molecular sieve

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h

4.1: PPTA / dichloromethane / 2 h / 20 °C

4.2: -78 - 20 °C

5.1: dmap; sodium hydrogencarbonate / dichloromethane / 3 h / 0 °C

6.1: potassium hexamethylsilazane / tetrahydrofuran / 1 h / -78 °C

6.2: -78 - 20 °C

7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

8.1: NMO; tetrapropylammonium perruthennate / dichloromethane / 3 h / -30 °C / Molecular sieve

8.2: 0.42 h / -90 - -70 °C

9.1: tetrapropylammonium perruthennate; magnesium bromide ethyl etherate / dichloromethane / 3 h / 0 °C

10.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 0.83 h / 0 °C / pH 7

11.1: lithium aluminium tetrahydride / tetrahydrofuran / 65 h / -70 °C

12.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.25 h

13.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / 120 h / Darkness

14.1: camphor-10-sulfonic acid / acetone / 96 h

15.1: Zn-Ag couple / deuteromethanol / 5 h / Darkness

16.1: lithium hydroxide / methanol; tetrahydrofuran / 5 h / 20 °C

With titanium(IV) isopropylate; tert.-butylhydroperoxide; dmap; copper(l) iodide; lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrapropylammonium perruthennate; NMO; camphor-10-sulfonic acid; tetrabutyl ammonium fluoride; potassium hexamethylsilazane; sodium hydrogencarbonate; magnesium bromide ethyl etherate; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; deuteromethanol; acetone;
DOI:10.1021/ol403441c