5-[13-cyclohexyl-3-methoxy-10-[[[(1-methylethyl)sulfonyl]amino]carbonyl]-7H-indolo[2,1-a][2]benzazepin-6-yl]-1-(3-methyl-4-pyridinyl)-1H-pyrazole-4-carboxylic acid ethyl ester hydrochloride

Base Information

Chemical Name:5-[13-cyclohexyl-3-methoxy-10-[[[(1-methylethyl)sulfonyl]amino]carbonyl]-7H-indolo[2,1-a][2]benzazepin-6-yl]-1-(3-methyl-4-pyridinyl)-1H-pyrazole-4-carboxylic acid ethyl ester hydrochloride
CAS No.:1195782-34-3
Molecular Formula:C₄₀H₄₃N₅O₆S*ClH
Molecular Weight:758.338
Hs Code.:

5-[13-cyclohexyl-3-methoxy-10-[[[(1-methylethyl)sulfonyl]amino]carbonyl]-7H-indolo[2,1-a][2]benzazepin-6-yl]-1-(3-methyl-4-pyridinyl)-1H-pyrazole-4-carboxylic acid ethyl ester hydrochloride

Synonyms:5-[13-cyclohexyl-3-methoxy-10-[[[(1-methylethyl)sulfonyl]amino]carbonyl]-7H-indolo[2,1-a][2]benzazepin-6-yl]-1-(3-methyl-4-pyridinyl)-1H-pyrazole-4-carboxylic acid ethyl ester hydrochloride

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Chemical Property of 5-[13-cyclohexyl-3-methoxy-10-[[[(1-methylethyl)sulfonyl]amino]carbonyl]-7H-indolo[2,1-a][2]benzazepin-6-yl]-1-(3-methyl-4-pyridinyl)-1H-pyrazole-4-carboxylic acid ethyl ester hydrochloride

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Technology Process of 5-[13-cyclohexyl-3-methoxy-10-[[[(1-methylethyl)sulfonyl]amino]carbonyl]-7H-indolo[2,1-a][2]benzazepin-6-yl]-1-(3-methyl-4-pyridinyl)-1H-pyrazole-4-carboxylic acid ethyl ester hydrochloride

There total 4 articles about 5-[13-cyclohexyl-3-methoxy-10-[[[(1-methylethyl)sulfonyl]amino]carbonyl]-7H-indolo[2,1-a][2]benzazepin-6-yl]-1-(3-methyl-4-pyridinyl)-1H-pyrazole-4-carboxylic acid ethyl ester hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 81363-76-0
propane-2-sulfonamide

: 1195782-32-1
13-cyclohexyl-6-[4-(ethoxycarbonyl)-1-(3-methyl-4-pyridinyl)-1H-pyrazol-5-yl]-3-methoxy-7H-indolo[2,1-a][2]benzazepine-10-carboxylic acid hydrochloride

: 1195782-34-3
5-[13-cyclohexyl-3-methoxy-10-[[[(1-methylethyl)sulfonyl]amino]carbonyl]-7H-indolo[2,1-a][2]benzazepin-6-yl]-1-(3-methyl-4-pyridinyl)-1H-pyrazole-4-carboxylic acid ethyl ester hydrochloride

Guidance literature:: 13-cyclohexyl-6-[4-(ethoxycarbonyl)-1-(3-methyl-4-pyridinyl)-1H-pyrazol-5-yl]-3-methoxy-7H-indolo[2,1-a][2]benzazepine-10-carboxylic acid hydrochloride; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 20 ℃; for 1.75h; Inert atmosphere; Reflux;

propane-2-sulfonamide; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at 70 ℃; for 17h; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; water; ethyl acetate;

Reference yield:

: 1127234-87-0
13-cyclohexyl-10-[(1,1-dimethylethoxy)carbonyl]-3-methoxy-beta-oxo-7H-indolo[2,1-a][2]benzazepine-6-propanoic acid ethyl ester

: 1195782-34-3
5-[13-cyclohexyl-3-methoxy-10-[[[(1-methylethyl)sulfonyl]amino]carbonyl]-7H-indolo[2,1-a][2]benzazepin-6-yl]-1-(3-methyl-4-pyridinyl)-1H-pyrazole-4-carboxylic acid ethyl ester hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: 2.75 h / 110 °C / Inert atmosphere

2.1: triethylamine / 1,4-dioxane; ethanol / 0.67 h / 140 °C / Inert atmosphere; microwave

3.1: trifluoroacetic acid / 1,2-dichloro-ethane / 2 h / 20 °C / Inert atmosphere

4.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1.75 h / 20 °C / Inert atmosphere; Reflux

4.2: 17 h / 70 °C / Inert atmosphere

With triethylamine; 1,1'-carbonyldiimidazole; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; ethanol; 1,2-dichloro-ethane;

Reference yield:

: 1127234-89-2
tert-butyl 13-cyclohexyl-6-((2E,Z)-3-(dimethylamino)-2-(ethoxycarbonyl)-2-propenoyl)-3-methoxy-7H-indolo[2,1-a][2]benzazepine-10-carboxylate

: 1195782-34-3
5-[13-cyclohexyl-3-methoxy-10-[[[(1-methylethyl)sulfonyl]amino]carbonyl]-7H-indolo[2,1-a][2]benzazepin-6-yl]-1-(3-methyl-4-pyridinyl)-1H-pyrazole-4-carboxylic acid ethyl ester hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / 1,4-dioxane; ethanol / 0.67 h / 140 °C / Inert atmosphere; microwave

2.1: trifluoroacetic acid / 1,2-dichloro-ethane / 2 h / 20 °C / Inert atmosphere

3.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1.75 h / 20 °C / Inert atmosphere; Reflux

3.2: 17 h / 70 °C / Inert atmosphere

With triethylamine; 1,1'-carbonyldiimidazole; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; ethanol; 1,2-dichloro-ethane;