Technology Process of (S)-6-((6-(benzyloxy)-7-methoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)methyl)-2,3-dimethoxylbenzyl acetate
There total 14 articles about (S)-6-((6-(benzyloxy)-7-methoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)methyl)-2,3-dimethoxylbenzyl acetate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
formic acid; triethylamine;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 8h;
Inert atmosphere;
DOI:10.1016/j.bmcl.2017.01.090
- Guidance literature:
-
Multi-step reaction with 4 steps
1: ethanol / 14 h / Reflux
2: pyridine / dichloromethane / 1.5 h / 0 - 20 °C
3: trichlorophosphate / acetonitrile / 1 h / Reflux; Inert atmosphere
4: (1S,2S)-(+)-N-tosyl-1,2-diphenylethane-1,2-diamine[η6-1-isopropyl-4-methylbenzene]-ruthenium(II); formic acid; triethylamine / N,N-dimethyl-formamide / 20 °C
With
pyridine; (1S,2S)-(+)-N-tosyl-1,2-diphenylethane-1,2-diamine[η6-1-isopropyl-4-methylbenzene]-ruthenium(II); formic acid; triethylamine; trichlorophosphate;
In
ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
3: |Bischler-Napieralski Reaction;
DOI:10.1016/j.bmc.2012.12.016
- Guidance literature:
-
Multi-step reaction with 5 steps
1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / Reflux
2: ethanol / 14 h / Reflux
3: pyridine / dichloromethane / 1.5 h / 0 - 20 °C
4: trichlorophosphate / acetonitrile / 1 h / Reflux; Inert atmosphere
5: (1S,2S)-(+)-N-tosyl-1,2-diphenylethane-1,2-diamine[η6-1-isopropyl-4-methylbenzene]-ruthenium(II); formic acid; triethylamine / N,N-dimethyl-formamide / 20 °C
With
pyridine; lithium aluminium tetrahydride; (1S,2S)-(+)-N-tosyl-1,2-diphenylethane-1,2-diamine[η6-1-isopropyl-4-methylbenzene]-ruthenium(II); formic acid; triethylamine; trichlorophosphate;
In
tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
4: |Bischler-Napieralski Reaction;
DOI:10.1016/j.bmc.2012.12.016
