(S)-N-((3-(3-fluoro-4-(1-(hydroxyacetyl)[1,2,5]triazepan-5-yl)phenyl)-2-oxo-5-oxazolidinyl)methyl)acetamide

Base Information

Chemical Name:(S)-N-((3-(3-fluoro-4-(1-(hydroxyacetyl)[1,2,5]triazepan-5-yl)phenyl)-2-oxo-5-oxazolidinyl)methyl)acetamide
CAS No.:952150-57-1
Molecular Formula:C₁₈H₂₄FN₅O₅
Molecular Weight:409.417
Hs Code.:

Synonyms:(S)-N-((3-(3-fluoro-4-(1-(hydroxyacetyl)[1,2,5]triazepan-5-yl)phenyl)-2-oxo-5-oxazolidinyl)methyl)acetamide

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Chemical Property of (S)-N-((3-(3-fluoro-4-(1-(hydroxyacetyl)[1,2,5]triazepan-5-yl)phenyl)-2-oxo-5-oxazolidinyl)methyl)acetamide

Chemical Property:

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Technology Process of (S)-N-((3-(3-fluoro-4-(1-(hydroxyacetyl)[1,2,5]triazepan-5-yl)phenyl)-2-oxo-5-oxazolidinyl)methyl)acetamide

There total 13 articles about (S)-N-((3-(3-fluoro-4-(1-(hydroxyacetyl)[1,2,5]triazepan-5-yl)phenyl)-2-oxo-5-oxazolidinyl)methyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₃H₃₂FN₅O₇

: 952150-57-1
(S)-N-((3-(3-fluoro-4-(1-(hydroxyacetyl)[1,2,5]triazepan-5-yl)phenyl)-2-oxo-5-oxazolidinyl)methyl)acetamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1016/j.ejmech.2013.03.003

Reference yield:

: 369-34-6
3,4-difluoronitrobenzene

: 952150-57-1
(S)-N-((3-(3-fluoro-4-(1-(hydroxyacetyl)[1,2,5]triazepan-5-yl)phenyl)-2-oxo-5-oxazolidinyl)methyl)acetamide

Guidance literature:: Multi-step reaction with 12 steps

1.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 16 h / Reflux

2.1: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 20 °C / 760.05 Torr

3.1: sodium carbonate / methanol / 0.5 h

4.1: n-butyllithium / hexane; tetrahydrofuran / 0.17 h / -78 °C / Inert atmosphere

4.2: 23.17 h / -78 - 20 °C / Inert atmosphere

5.1: triethylamine / dichloromethane / 0.17 h / 0 - 20 °C

6.1: sodium azide / N,N-dimethyl-formamide / 4 h / 80 - 90 °C

7.1: triphenylphosphine / tetrahydrofuran; water / 2 h / Reflux

8.1: pyridine / dichloromethane / 0.5 h / 20 °C

9.1: palladium 10% on activated carbon; hydrogen / methanol / 21 h / 20 °C / 760.05 Torr

10.1: pyridine / dichloromethane / 0.17 h

11.1: potassium carbonate / methanol / 0.17 h / 20 °C

12.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

With pyridine; n-butyllithium; sodium azide; palladium 10% on activated carbon; hydrogen; sodium carbonate; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; methanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.ejmech.2013.03.003

Reference yield:

: 1443005-30-8
5-(2-fluoro-4-nitrophenyl)[1,2,5]triazepane-1-carboxylic acid tert-butyl ester

: 952150-57-1
(S)-N-((3-(3-fluoro-4-(1-(hydroxyacetyl)[1,2,5]triazepan-5-yl)phenyl)-2-oxo-5-oxazolidinyl)methyl)acetamide

Guidance literature:: Multi-step reaction with 11 steps

1.1: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 20 °C / 760.05 Torr

2.1: sodium carbonate / methanol / 0.5 h

3.1: n-butyllithium / hexane; tetrahydrofuran / 0.17 h / -78 °C / Inert atmosphere

3.2: 23.17 h / -78 - 20 °C / Inert atmosphere

4.1: triethylamine / dichloromethane / 0.17 h / 0 - 20 °C

5.1: sodium azide / N,N-dimethyl-formamide / 4 h / 80 - 90 °C

6.1: triphenylphosphine / tetrahydrofuran; water / 2 h / Reflux

7.1: pyridine / dichloromethane / 0.5 h / 20 °C

8.1: palladium 10% on activated carbon; hydrogen / methanol / 21 h / 20 °C / 760.05 Torr

9.1: pyridine / dichloromethane / 0.17 h

10.1: potassium carbonate / methanol / 0.17 h / 20 °C

11.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

With pyridine; n-butyllithium; sodium azide; palladium 10% on activated carbon; hydrogen; sodium carbonate; potassium carbonate; triethylamine; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; methanol; hexane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2013.03.003