(1S,3R)-N-[(1R)-1-(naphthalen-1-yl)ethyl]-3-[4-(2H-tetrazol-5-ylmethoxy)phenyl]cyclopentanamine

Base Information

Chemical Name:(1S,3R)-N-[(1R)-1-(naphthalen-1-yl)ethyl]-3-[4-(2H-tetrazol-5-ylmethoxy)phenyl]cyclopentanamine
CAS No.:1211474-25-7
Molecular Formula:C₂₅H₂₇N₅O
Molecular Weight:413.522
Hs Code.:

Synonyms:(1S,3R)-N-[(1R)-1-(naphthalen-1-yl)ethyl]-3-[4-(2H-tetrazol-5-ylmethoxy)phenyl]cyclopentanamine

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Chemical Property of (1S,3R)-N-[(1R)-1-(naphthalen-1-yl)ethyl]-3-[4-(2H-tetrazol-5-ylmethoxy)phenyl]cyclopentanamine

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Technology Process of (1S,3R)-N-[(1R)-1-(naphthalen-1-yl)ethyl]-3-[4-(2H-tetrazol-5-ylmethoxy)phenyl]cyclopentanamine

There total 3 articles about (1S,3R)-N-[(1R)-1-(naphthalen-1-yl)ethyl]-3-[4-(2H-tetrazol-5-ylmethoxy)phenyl]cyclopentanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1211474-22-4
{4-[(1R,3S)-3-{[(1R)-1-(naphthalen-1-yl)ethyl]amino}cyclopentyl]phenoxy}acetonitrile

: 1211474-25-7
(1S,3R)-N-[(1R)-1-(naphthalen-1-yl)ethyl]-3-[4-(2H-tetrazol-5-ylmethoxy)phenyl]cyclopentanamine

Guidance literature:: With sodium azide; ammonium chloride; In N,N-dimethyl-formamide; at 80 ℃; for 3h; Inert atmosphere;

Reference yield:

: 1211473-15-2
(1S,3R)-3-[4-(benzyloxy)phenyl]-N-[(1R)-1-(naphthalen-1-yl)ethyl]cyclopentanamine

: 1211474-25-7
(1S,3R)-N-[(1R)-1-(naphthalen-1-yl)ethyl]-3-[4-(2H-tetrazol-5-ylmethoxy)phenyl]cyclopentanamine

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / palladium 10% on activated carbon / methanol / 16 h / 20 °C / Inert atmosphere

2: potassium carbonate / N,N-dimethyl-formamide / 120 h / 20 °C / Inert atmosphere

3: sodium azide; ammonium chloride / N,N-dimethyl-formamide / 3 h / 80 °C / Inert atmosphere

With sodium azide; hydrogen; potassium carbonate; ammonium chloride; palladium 10% on activated carbon; In methanol; N,N-dimethyl-formamide;

Reference yield:

: 1157580-74-9
4-[(1R,3S)-3-{[(1R)-1-(naphthalen-1-yl)ethyl]amino}cyclopentyl]phenol

: 1211474-25-7
(1S,3R)-N-[(1R)-1-(naphthalen-1-yl)ethyl]-3-[4-(2H-tetrazol-5-ylmethoxy)phenyl]cyclopentanamine

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 120 h / 20 °C / Inert atmosphere

2: sodium azide; ammonium chloride / N,N-dimethyl-formamide / 3 h / 80 °C / Inert atmosphere

With sodium azide; potassium carbonate; ammonium chloride; In N,N-dimethyl-formamide;