methyl 7-{4-fluoro-2-[(Z)-3-((R)-3-acetoxypyrrolidin-1-yl)-prop-1-enyl]-benzenesulfonylamino}-4H-furo[2,3-c]chromene-6-carboxylate

Base Information

Chemical Name:methyl 7-{4-fluoro-2-[(Z)-3-((R)-3-acetoxypyrrolidin-1-yl)-prop-1-enyl]-benzenesulfonylamino}-4H-furo[2,3-c]chromene-6-carboxylate
CAS No.:1356113-65-9
Molecular Formula:C₂₈H₂₇FN₂O₈S
Molecular Weight:570.595
Hs Code.:

Synonyms:methyl 7-{4-fluoro-2-[(Z)-3-((R)-3-acetoxypyrrolidin-1-yl)-prop-1-enyl]-benzenesulfonylamino}-4H-furo[2,3-c]chromene-6-carboxylate

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Chemical Property of methyl 7-{4-fluoro-2-[(Z)-3-((R)-3-acetoxypyrrolidin-1-yl)-prop-1-enyl]-benzenesulfonylamino}-4H-furo[2,3-c]chromene-6-carboxylate

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Technology Process of methyl 7-{4-fluoro-2-[(Z)-3-((R)-3-acetoxypyrrolidin-1-yl)-prop-1-enyl]-benzenesulfonylamino}-4H-furo[2,3-c]chromene-6-carboxylate

There total 8 articles about methyl 7-{4-fluoro-2-[(Z)-3-((R)-3-acetoxypyrrolidin-1-yl)-prop-1-enyl]-benzenesulfonylamino}-4H-furo[2,3-c]chromene-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1356113-67-1
acetic acid (R)-1-((Z)-3-tributylstannanylallyl)-pyrrolidin-3-yl ester

: 1356111-72-2
methyl 7-(2-bromo-4-fluorobenzenesulfonylamino)-4H-furo[2,3-c]chromene-6-carboxylate

: 1356113-65-9
methyl 7-{4-fluoro-2-[(Z)-3-((R)-3-acetoxypyrrolidin-1-yl)-prop-1-enyl]-benzenesulfonylamino}-4H-furo[2,3-c]chromene-6-carboxylate

Guidance literature:: With tri tert-butylphosphoniumtetrafluoroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; acetic acid; dimethyl sulfoxide; at 50 ℃; for 2h; Inert atmosphere;

Reference yield:

: 681247-11-0
methyl 6-amino-3-bromo-2-hydroxybenzoate

: 1356113-65-9
methyl 7-{4-fluoro-2-[(Z)-3-((R)-3-acetoxypyrrolidin-1-yl)-prop-1-enyl]-benzenesulfonylamino}-4H-furo[2,3-c]chromene-6-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: caesium carbonate; tri tert-butylphosphoniumtetrafluoroborate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 65 °C / Inert atmosphere

2.1: dmap; triethylamine / dichloromethane / 1 h

2.2: 2 h

3.1: ethanol; sodium tetrahydroborate / 0.25 h

4.1: sodium hydroxide; water / methanol / 1.5 h / 45 °C

5.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 1 h / 20 °C

5.2: 1 h

6.1: hydrogenchloride / 1,4-dioxane / 1.5 h

6.2: 18 h

7.1: tri tert-butylphosphoniumtetrafluoroborate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane; dimethyl sulfoxide; acetic acid / 2 h / 50 °C / Inert atmosphere

With hydrogenchloride; dmap; sodium tetrahydroborate; ethanol; carbon tetrabromide; water; caesium carbonate; triethylamine; triphenylphosphine; sodium hydroxide; tri tert-butylphosphoniumtetrafluoroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; methanol; dichloromethane; water; acetic acid; dimethyl sulfoxide;

Reference yield:

: 1055881-23-6
3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)furan-2-carbaldehyde

: 1356113-65-9
methyl 7-{4-fluoro-2-[(Z)-3-((R)-3-acetoxypyrrolidin-1-yl)-prop-1-enyl]-benzenesulfonylamino}-4H-furo[2,3-c]chromene-6-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: caesium carbonate; tri tert-butylphosphoniumtetrafluoroborate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 65 °C / Inert atmosphere

2.1: dmap; triethylamine / dichloromethane / 1 h

2.2: 2 h

3.1: ethanol; sodium tetrahydroborate / 0.25 h

4.1: sodium hydroxide; water / methanol / 1.5 h / 45 °C

5.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 1 h / 20 °C

5.2: 1 h

6.1: hydrogenchloride / 1,4-dioxane / 1.5 h

6.2: 18 h

7.1: tri tert-butylphosphoniumtetrafluoroborate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane; dimethyl sulfoxide; acetic acid / 2 h / 50 °C / Inert atmosphere

With hydrogenchloride; dmap; sodium tetrahydroborate; ethanol; carbon tetrabromide; water; caesium carbonate; triethylamine; triphenylphosphine; sodium hydroxide; tri tert-butylphosphoniumtetrafluoroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; methanol; dichloromethane; water; acetic acid; dimethyl sulfoxide;