p-nitrobenzyl (RS)-7-(3-benzothienylglycylamido)-3-methyl-3-cephem-4-carboxylate p-toluenesulfonic acid salt

Base Information

Chemical Name:p-nitrobenzyl (RS)-7-(3-benzothienylglycylamido)-3-methyl-3-cephem-4-carboxylate p-toluenesulfonic acid salt
CAS No.:95834-71-2
Molecular Formula:C₇H₈O₃S*C₂₅H₂₂N₄O₆S₂
Molecular Weight:710.81
Hs Code.:

Synonyms:p-nitrobenzyl (RS)-7-(3-benzothienylglycylamido)-3-methyl-3-cephem-4-carboxylate p-toluenesulfonic acid salt

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Chemical Property of p-nitrobenzyl (RS)-7-(3-benzothienylglycylamido)-3-methyl-3-cephem-4-carboxylate p-toluenesulfonic acid salt

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Technology Process of p-nitrobenzyl (RS)-7-(3-benzothienylglycylamido)-3-methyl-3-cephem-4-carboxylate p-toluenesulfonic acid salt

There total 4 articles about p-nitrobenzyl (RS)-7-(3-benzothienylglycylamido)-3-methyl-3-cephem-4-carboxylate p-toluenesulfonic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 95835-19-1
<2-(hydroxyimino)-3-benzothienyl>acetic acid

: 95834-71-2
p-nitrobenzyl (RS)-7-(3-benzothienylglycylamido)-3-methyl-3-cephem-4-carboxylate p-toluenesulfonic acid salt

Guidance literature:: Multi-step reaction with 4 steps

1: 1.35 g / H₂ / 5 percent Pd/C / methanol / 3 h / 24 °C / 3102.9 Torr

2: 92 percent / Et₃N / H₂O; tetrahydrofuran

3: 95 percent / EEDQ / tetrahydrofuran; acetonitrile / 5.5 h / 25 °C

4: acetonitrile / 72 h / 25 °C

With hydrogen; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; water; acetonitrile;
DOI:10.1021/jm00150a024

Reference yield:

: 95834-55-2
(RS)-3-benzothienylglycine

: 95834-71-2
p-nitrobenzyl (RS)-7-(3-benzothienylglycylamido)-3-methyl-3-cephem-4-carboxylate p-toluenesulfonic acid salt

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / Et₃N / H₂O; tetrahydrofuran

2: 95 percent / EEDQ / tetrahydrofuran; acetonitrile / 5.5 h / 25 °C

3: acetonitrile / 72 h / 25 °C

With N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; triethylamine; In tetrahydrofuran; water; acetonitrile;
DOI:10.1021/jm00150a024

Reference yield:

: 95834-98-3
(RS)-N-(tert-butoxycarbonyl)-3-benzothienylglycine

: 95834-71-2
p-nitrobenzyl (RS)-7-(3-benzothienylglycylamido)-3-methyl-3-cephem-4-carboxylate p-toluenesulfonic acid salt

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / EEDQ / tetrahydrofuran; acetonitrile / 5.5 h / 25 °C

2: acetonitrile / 72 h / 25 °C

With N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; In tetrahydrofuran; acetonitrile;
DOI:10.1021/jm00150a024