7-(4-trifluoromethylphenyl)-2,3-dihydro-1-benzoxepine-4-carboxylic acid

Base Information

Chemical Name:7-(4-trifluoromethylphenyl)-2,3-dihydro-1-benzoxepine-4-carboxylic acid
CAS No.:229007-84-5
Molecular Formula:C₁₈H₁₃F₃O₃
Molecular Weight:334.295
Hs Code.:

Synonyms:7-(4-trifluoromethylphenyl)-2,3-dihydro-1-benzoxepine-4-carboxylic acid

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Chemical Property of 7-(4-trifluoromethylphenyl)-2,3-dihydro-1-benzoxepine-4-carboxylic acid

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Technology Process of 7-(4-trifluoromethylphenyl)-2,3-dihydro-1-benzoxepine-4-carboxylic acid

There total 6 articles about 7-(4-trifluoromethylphenyl)-2,3-dihydro-1-benzoxepine-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 229007-83-4
ethyl 7-(4-trifluoromethylphenyl)-2,3-dihydro-1-benzoxepine-4-carboxylate

: 229007-84-5
7-(4-trifluoromethylphenyl)-2,3-dihydro-1-benzoxepine-4-carboxylic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; methanol; at 20 ℃;
DOI:10.1021/jm9906264

Reference yield:

: 4068-76-2
5-bromo-2-hydroxy-benzoic acid methyl ester

: 229007-84-5
7-(4-trifluoromethylphenyl)-2,3-dihydro-1-benzoxepine-4-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 87 percent / K₂CO₃ / dimethylformamide / 20 °C

2: lithium diisopropylamide / hexane; tetrahydrofuran / -78 - 20 °C

3: NaBH₄ / methanol; CH₂Cl₂ / 1 h / -10 °C

4: 41 percent / methanesulfonyl chloride; Et₃N / CH₂Cl₂ / 20 °C

5: 80 percent / tetrakis(triphenylphosphine)palladium; 2 M aq. K₂CO₃ / ethanol; toluene / Heating

6: 97 percent / 1 N aq. NaOH / methanol; tetrahydrofuran / 20 °C

With sodium hydroxide; sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; methanesulfonyl chloride; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; N,N-dimethyl-formamide; toluene; 1: Alkylation / 2: Dieckmann condensation / 3: Reduction / 4: Dehydration / 5: Suzuki coupling / 6: Hydrolysis;
DOI:10.1021/jm9906264

Reference yield:

: 229007-43-6
ethyl 7-bromo-2,3-dihydro-1-benzoxepine-4-carboxylate

: 229007-84-5
7-(4-trifluoromethylphenyl)-2,3-dihydro-1-benzoxepine-4-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / tetrakis(triphenylphosphine)palladium; 2 M aq. K₂CO₃ / ethanol; toluene / Heating

2: 97 percent / 1 N aq. NaOH / methanol; tetrahydrofuran / 20 °C

With sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In tetrahydrofuran; methanol; ethanol; toluene; 1: Suzuki coupling / 2: Hydrolysis;
DOI:10.1021/jm9906264