(2R^*,3S^*)-4-amino-2-(2,4-dichlorophenyl)-3-methyl-1-(1H-1,2,4-triazol-1-yl)-4-<4-(trifluoromethyl)benzoylamino>-2-butanol

Base Information

• Chemical Name: (2R^*,3S^*)-4-amino-2-(2,4-dichlorophenyl)-3-methyl-1-(1H-1,2,4-triazol-1-yl)-4-<4-(trifluoromethyl)benzoylamino>-2-butanol
• CAS No.: 126917-40-6
• Molecular Formula: C₂₁H₁₉Cl₂F₃N₄O₂
• Molecular Weight: 487.309

Synonyms:(2R^*,3S^*)-4-amino-2-(2,4-dichlorophenyl)-3-methyl-1-(1H-1,2,4-triazol-1-yl)-4-<4-(trifluoromethyl)benzoylamino>-2-butanol

Chemical Property of (2R^*,3S^*)-4-amino-2-(2,4-dichlorophenyl)-3-methyl-1-(1H-1,2,4-triazol-1-yl)-4-<4-(trifluoromethyl)benzoylamino>-2-butanol

Chemical Property:

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Technology Process of (2R^*,3S^*)-4-amino-2-(2,4-dichlorophenyl)-3-methyl-1-(1H-1,2,4-triazol-1-yl)-4-<4-(trifluoromethyl)benzoylamino>-2-butanol

There total 8 articles about (2R^*,3S^*)-4-amino-2-(2,4-dichlorophenyl)-3-methyl-1-(1H-1,2,4-triazol-1-yl)-4-<4-(trifluoromethyl)benzoylamino>-2-butanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

4-trifluoromethyl-phenyl acetyl chloride (329-15-7) + (2R*,3S*)-4-amino-2-(2,4-dichlorophenyl)-3-methyl-1-(1H-1,2,4-triazol-1-yl)-2-butanol (126917-39-3,141619-59-2) → (2R*,3S*)-4-amino-2-(2,4-dichlorophenyl)-3-methyl-1-(1H-1,2,4-triazol-1-yl)-4-<4-(trifluoromethyl)benzoylamino>-2-butanol (126917-40-6)

Guidance literature:

With pyridine; at 0 ℃; for 0.5h;

DOI:10.1248/cpb.40.661

Reference yield:

2-(2,4-Dichloro-phenyl)-2-(1-methyl-allyl)-oxirane (141619-53-6) → (2R*,3S*)-4-amino-2-(2,4-dichlorophenyl)-3-methyl-1-(1H-1,2,4-triazol-1-yl)-4-<4-(trifluoromethyl)benzoylamino>-2-butanol (126917-40-6)

Guidance literature:

Multi-step reaction with 7 steps

1: 1.) NaH / 1.) DMF, 0 deg C, 2.) DMF, 120 deg C, 2 h

2: 63 percent / NaIO₄, OsO₄ / H₂O; tetrahydrofuran / Ambient temperature

3: 88 percent / NaBH₄ / methanol / 0.17 h / 0 °C

4: Et₃N / CH₂Cl₂ / 0.25 h / 0 °C

5: 69 percent / NaN₃ / dimethylformamide / 3 h / 100 °C

6: 100 percent / H₂ / 10percent Pd/C / ethanol / 1 h

7: 75 percent / pyridine / 0.5 h / 0 °C

With pyridine; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; sodium azide; hydrogen; sodium hydride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1248/cpb.40.661

Reference yield:

(2R*,3S*)-4-azido-2-(2,4-dichlorophenyl)-3-methyl-1-(1H-1,2,4-triazol-1-yl)-2-butanol → (2R*,3S*)-4-amino-2-(2,4-dichlorophenyl)-3-methyl-1-(1H-1,2,4-triazol-1-yl)-4-<4-(trifluoromethyl)benzoylamino>-2-butanol (126917-40-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / H₂ / 10percent Pd/C / ethanol / 1 h

2: 75 percent / pyridine / 0.5 h / 0 °C

With pyridine; hydrogen; palladium on activated charcoal; In ethanol;

DOI:10.1248/cpb.40.661

upstream raw materials:

4-trifluoromethyl-phenyl acetyl chloride

(2R^*,3S^*)-4-amino-2-(2,4-dichlorophenyl)-3-methyl-1-(1H-1,2,4-triazol-1-yl)-2-butanol

2-(2,4-Dichloro-phenyl)-2-(1-methyl-allyl)-oxirane

(2R^*,3S^*)-2-(2,4-dichlorophenyl)-4-methanesulfonyloxy-3-methyl-1-(1H-1,2,4-triazol-1-yl)-2-butanol

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