(2R)-2-fluoro-2--3-phenylpropanoic acid benzylamide

Base Information

Chemical Name:(2R)-2-fluoro-2--3-phenylpropanoic acid benzylamide
CAS No.:160000-11-3
Molecular Formula:C₂₅H₂₅FN₂O₃
Molecular Weight:420.484
Hs Code.:

(2R)-2-fluoro-2-<N-methyl-N-(p-methoxyphenyl)carbonyl>-3-phenylpropanoic acid benzylamide

Synonyms:(2R)-2-fluoro-2--3-phenylpropanoic acid benzylamide

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Chemical Property of (2R)-2-fluoro-2--3-phenylpropanoic acid benzylamide

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Technology Process of (2R)-2-fluoro-2--3-phenylpropanoic acid benzylamide

There total 3 articles about (2R)-2-fluoro-2--3-phenylpropanoic acid benzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 160000-10-2
(2S)-2-fluoro-2--3-phenylpropanoic acid

: 100-46-9
benzylamine

: 160000-11-3
(2R)-2-fluoro-2--3-phenylpropanoic acid benzylamide

Guidance literature:: With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; at 0 - 20 ℃; for 16h;
DOI:10.1016/0957-4166(94)80050-2

Reference yield:

: 160000-09-9
(2R)-2-fluoro-2--3-phenylpropanol

: 160000-11-3
(2R)-2-fluoro-2--3-phenylpropanoic acid benzylamide

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / CrO₃, H₂SO₄ / acetone / 2 h / Ambient temperature

2: 79 percent / 1-hydroxybenzotriazole, dicyclohexylcarbodiimide / tetrahydrofuran / 16 h / 0 - 20 °C

With chromium(VI) oxide; sulfuric acid; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; acetone;
DOI:10.1016/0957-4166(94)80050-2

Reference yield:

: 160000-08-8
(2R)-2-benzyl-2-fluoro-3-(tert-butyldimethylsilyloxy)-N-methyl-N-(p-methoxyphenyl)propionamide

: 160000-11-3
(2R)-2-fluoro-2--3-phenylpropanoic acid benzylamide

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / Bu₄NF / tetrahydrofuran / 0.5 h / Ambient temperature

2: 80 percent / CrO₃, H₂SO₄ / acetone / 2 h / Ambient temperature

3: 79 percent / 1-hydroxybenzotriazole, dicyclohexylcarbodiimide / tetrahydrofuran / 16 h / 0 - 20 °C

With chromium(VI) oxide; sulfuric acid; tetrabutyl ammonium fluoride; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; acetone;
DOI:10.1016/0957-4166(94)80050-2