2-Amino-2-(2-fluorophenyl)ethanol

Base Information

• Chemical Name: 2-Amino-2-(2-fluorophenyl)ethanol
• CAS No.: 179811-62-2
• Molecular Formula: C₈H₁₀FNO
• Molecular Weight: 155.172
• Hs Code.: 2922190090
• DSSTox Substance ID: DTXSID20564730
• Mol file: 179811-62-2.mol

Synonyms:2-amino-2-(2-fluorophenyl)ethanol;179811-62-2;2-Amino-2-(2-fluorophenyl)ethan-1-ol;b-Amino-2-fluorobenzeneethanol;BENZENEETHANOL, BETA-AMINO-2-FLUORO-;(betaR)-beta-Amino-2-fluorobenzeneethanol;SCHEMBL1332822;beta-Amino-2-fluorobenzeneethanol;DTXSID20564730;SZOFSDXTFGOZLA-UHFFFAOYSA-N;AKOS005265465;SB45087;SB75977;SB84164;Benzeneethanol,beta-amino-2-fluoro-(9ci);BS-12260;CS-0377020;EN300-146097;I11143;F8887-4536

Chemical Property of 2-Amino-2-(2-fluorophenyl)ethanol

Chemical Property:

• PSA: 46.25000
• LogP: 1.51810
• XLogP3: 0.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 155.074642105
• Heavy Atom Count: 11
• Complexity: 121

Purity/Quality:

98.5% ^*data from raw suppliers

2-Amino-2-(2-fluorophenyl)ethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)C(CO)N)F

Technology Process of 2-Amino-2-(2-fluorophenyl)ethanol

There total 18 articles about 2-Amino-2-(2-fluorophenyl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(Rs,1S)-N-(2-(tert-butyldimethylsilyloxy)-1-(2-fluorophenyl)ethyl)-2-methylpropane-2-sulfinamide (1312719-17-7) → (S)-2-amino-2-(2-fluorophenyl)ethan-1-ol (1213876-57-3,179811-62-2,224434-02-0)

Guidance literature:

(Rs,1S)-N-(2-(tert-butyldimethylsilyloxy)-1-(2-fluorophenyl)ethyl)-2-methylpropane-2-sulfinamide; With hydrogenchloride; In methanol; at 20 ℃; for 3h;

With sodium hydrogencarbonate; In water;

DOI:10.1016/j.tetasy.2011.01.011

Reference yield: 90.0%

[(S)-1-(2-Fluoro-phenyl)-2-hydroxy-ethyl]-carbamic acid benzyl ester (224434-00-8) → (S)-2-amino-2-(2-fluorophenyl)ethan-1-ol (1213876-57-3,179811-62-2,224434-02-0)

Guidance literature:

With hydrogen; palladium dihydroxide; In methanol; for 0.25h;

DOI:10.1016/S0040-4020(99)00064-2

Reference yield:

C12H18FNO2S → (R)-2-amino-2-(2-fluorophenyl)ethanol (1213876-57-3,179811-62-2,224434-02-0)

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 20 ℃; for 1h;

upstream raw materials:

[(S)-1-(2-Fluoro-phenyl)-2-hydroxy-ethyl]-carbamic acid benzyl ester

2-Fluorobenzaldehyde

1-(2-Fluorophenyl)-N-(4-methoxyphenyl)methanimine

(S)-1-(2-Fluoro-phenyl)-2-((R)-toluene-4-sulfinyl)-ethylamine

Downstream raw materials:

C₁₃H₁₈FNO₃

6-((2R,5R)-5-(2-fluorophenyl)-2-methylmorpholino)-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one