methyl 2,2-dimethyl-4-[4-(4-methyl-6-{[4-(trifluoromethyl)pyridin-2-yl]amino}pyridin-2-yl)-1H-1,2,3-triazol-1-yl]cyclohexanecarboxylate

Base Information

Chemical Name:methyl 2,2-dimethyl-4-[4-(4-methyl-6-{[4-(trifluoromethyl)pyridin-2-yl]amino}pyridin-2-yl)-1H-1,2,3-triazol-1-yl]cyclohexanecarboxylate
CAS No.:1582758-46-0
Molecular Formula:C₂₄H₂₇F₃N₆O₂
Molecular Weight:488.513
Hs Code.:

Synonyms:methyl 2,2-dimethyl-4-[4-(4-methyl-6-{[4-(trifluoromethyl)pyridin-2-yl]amino}pyridin-2-yl)-1H-1,2,3-triazol-1-yl]cyclohexanecarboxylate

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Chemical Property of methyl 2,2-dimethyl-4-[4-(4-methyl-6-{[4-(trifluoromethyl)pyridin-2-yl]amino}pyridin-2-yl)-1H-1,2,3-triazol-1-yl]cyclohexanecarboxylate

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Technology Process of methyl 2,2-dimethyl-4-[4-(4-methyl-6-{[4-(trifluoromethyl)pyridin-2-yl]amino}pyridin-2-yl)-1H-1,2,3-triazol-1-yl]cyclohexanecarboxylate

There total 6 articles about methyl 2,2-dimethyl-4-[4-(4-methyl-6-{[4-(trifluoromethyl)pyridin-2-yl]amino}pyridin-2-yl)-1H-1,2,3-triazol-1-yl]cyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1582753-91-0
6-ethynyl-4-methyl-N-[4-(trifluoromethyl)pyridin-2-yl]pyridin-2-amine

: methyl 4-azido-2,2-dimethylcyclohexanecarboxylate

: 1582758-46-0
methyl 2,2-dimethyl-4-[4-(4-methyl-6-{[4-(trifluoromethyl)pyridin-2-yl]amino}pyridin-2-yl)-1H-1,2,3-triazol-1-yl]cyclohexanecarboxylate

Guidance literature:: With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In water; tert-butyl alcohol; at 65 ℃; for 17h;

Reference yield:

: 35490-07-4,134209-76-0
methyl 2-methyl-4-oxocyclohex-2-enecarboxylate

: 1582758-46-0
methyl 2,2-dimethyl-4-[4-(4-methyl-6-{[4-(trifluoromethyl)pyridin-2-yl]amino}pyridin-2-yl)-1H-1,2,3-triazol-1-yl]cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: copper(l) iodide / diethyl ether / 3 h / -40 °C

1.2: 5 h / -40 - -20 °C

2.1: sodium tetrahydroborate; ethanol / 2 h / -20 °C

3.1: triethylamine / dichloromethane / 3 h / -20 °C

4.1: sodium azide / N,N-dimethyl-formamide / 19 h / 90 °C

5.1: copper(ll) sulfate pentahydrate; sodium L-ascorbate / water; tert-butyl alcohol / 17 h / 65 °C

With sodium tetrahydroborate; copper(l) iodide; sodium azide; copper(ll) sulfate pentahydrate; ethanol; sodium L-ascorbate; triethylamine; In diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 1312535-33-3
dimethyl 2-methyl-6-oxocyclohex-1-ene-1,3-dicarboxylate

: 1582758-46-0
methyl 2,2-dimethyl-4-[4-(4-methyl-6-{[4-(trifluoromethyl)pyridin-2-yl]amino}pyridin-2-yl)-1H-1,2,3-triazol-1-yl]cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium methylate; methanol / 1 h / 80 °C

2.1: copper(l) iodide / diethyl ether / 3 h / -40 °C

2.2: 5 h / -40 - -20 °C

3.1: sodium tetrahydroborate; ethanol / 2 h / -20 °C

4.1: triethylamine / dichloromethane / 3 h / -20 °C

5.1: sodium azide / N,N-dimethyl-formamide / 19 h / 90 °C

6.1: copper(ll) sulfate pentahydrate; sodium L-ascorbate / water; tert-butyl alcohol / 17 h / 65 °C

With methanol; sodium tetrahydroborate; copper(l) iodide; sodium azide; copper(ll) sulfate pentahydrate; ethanol; sodium methylate; sodium L-ascorbate; triethylamine; In diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;