Cbz-(S)β²hGlu(O-t-Bu)-OTMSE

Base Information

Chemical Name:Cbz-(S)β²hGlu(O-t-Bu)-OTMSE
CAS No.:764705-08-0
Molecular Formula:C₂₃H₃₇NO₆Si
Molecular Weight:451.635
Hs Code.:

Synonyms:Cbz-(S)β²hGlu(O-t-Bu)-OTMSE

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Chemical Property of Cbz-(S)β²hGlu(O-t-Bu)-OTMSE

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Technology Process of Cbz-(S)β²hGlu(O-t-Bu)-OTMSE

There total 1 articles about Cbz-(S)β²hGlu(O-t-Bu)-OTMSE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 2916-68-9
2-(Trimethylsilyl)ethanol

: 637337-69-0
(S)-2-({[(benzyloxy)carbonyl]amino}methyl)-4-[(tert-butoxy)carbonyl]butanoic acid

: 764705-08-0
Cbz-(S)β²hGlu(O-t-Bu)-OTMSE

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 ℃; for 16h;
DOI:10.1016/j.tet.2004.06.043

Reference yield:

: 764705-08-0
Cbz-(S)β²hGlu(O-t-Bu)-OTMSE

: Fmoc-(S)β²hAsn(Trt)-(S)β²hGlu(O-t-Bu)-OH

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / Pd/C / tetrahydrofuran

2: 1.39 g / N-methylmorpholine; [O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium]PF₆ / CH₂Cl₂ / 0 - 25 °C

3: TBAF*3H₂O / tetrahydrofuran / 24 h / 25 °C

With 4-methyl-morpholine; tetrabutyl ammonium fluoride; hydrogen; HATU; palladium on activated charcoal; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tet.2004.06.043

Reference yield:

: 764705-08-0
Cbz-(S)β²hGlu(O-t-Bu)-OTMSE

: 764705-10-4
Fmoc-(S)β²hAsn(Trt)-(S)β²hGlu(O-t-Bu)-OTMSE

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / Pd/C / tetrahydrofuran

2: 1.39 g / N-methylmorpholine; [O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium]PF₆ / CH₂Cl₂ / 0 - 25 °C

With 4-methyl-morpholine; hydrogen; HATU; palladium on activated charcoal; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tet.2004.06.043