((1R,3aR,4aS,6S,8aR,9S,9aS)-1-methyl-3-oxo-9-((E)-2-(5-(3-(trifluoromethyl)phenyl)pyridin-2-yl)vinyl)dodecahydronaphtho[2,3-c]furan-6-yl)methyl carbamate

Base Information

Chemical Name:((1R,3aR,4aS,6S,8aR,9S,9aS)-1-methyl-3-oxo-9-((E)-2-(5-(3-(trifluoromethyl)phenyl)pyridin-2-yl)vinyl)dodecahydronaphtho[2,3-c]furan-6-yl)methyl carbamate
CAS No.:1579952-83-2
Molecular Formula:C₂₉H₃₁F₃N₂O₄
Molecular Weight:528.571
Hs Code.:

((1R,3aR,4aS,6S,8aR,9S,9aS)-1-methyl-3-oxo-9-((E)-2-(5-(3-(trifluoromethyl)phenyl)pyridin-2-yl)vinyl)dodecahydronaphtho[2,3-c]furan-6-yl)methyl carbamate

Synonyms:((1R,3aR,4aS,6S,8aR,9S,9aS)-1-methyl-3-oxo-9-((E)-2-(5-(3-(trifluoromethyl)phenyl)pyridin-2-yl)vinyl)dodecahydronaphtho[2,3-c]furan-6-yl)methyl carbamate

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Chemical Property of ((1R,3aR,4aS,6S,8aR,9S,9aS)-1-methyl-3-oxo-9-((E)-2-(5-(3-(trifluoromethyl)phenyl)pyridin-2-yl)vinyl)dodecahydronaphtho[2,3-c]furan-6-yl)methyl carbamate

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Technology Process of ((1R,3aR,4aS,6S,8aR,9S,9aS)-1-methyl-3-oxo-9-((E)-2-(5-(3-(trifluoromethyl)phenyl)pyridin-2-yl)vinyl)dodecahydronaphtho[2,3-c]furan-6-yl)methyl carbamate

There total 3 articles about ((1R,3aR,4aS,6S,8aR,9S,9aS)-1-methyl-3-oxo-9-((E)-2-(5-(3-(trifluoromethyl)phenyl)pyridin-2-yl)vinyl)dodecahydronaphtho[2,3-c]furan-6-yl)methyl carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1579952-82-1
C₂₈H₃₀F₃NO₃

: 3019-71-4
Trichloroacetyl isocyanate

: 1579952-83-2
((1R,3aR,4aS,6S,8aR,9S,9aS)-1-methyl-3-oxo-9-((E)-2-(5-(3-(trifluoromethyl)phenyl)pyridin-2-yl)vinyl)dodecahydronaphtho[2,3-c]furan-6-yl)methyl carbamate

Guidance literature:: C₂₈H₃₀F₃NO₃; Trichloroacetyl isocyanate; In dichloromethane; for 0.583333h; Inert atmosphere;

With potassium carbonate; In methanol; dichloromethane; for 0.75h; Inert atmosphere;
DOI:10.1021/ml500008w

Reference yield:

: (3R,3aS,4S,4aR,8aR,9aR)-octahydro-3-methyl-4-[(E)-2-[5-[3-(trifluoromethyl)phenyl]-2-pyridinyl]ethenyl]naphtho[2,3-c]furan-1,7(3H,4H)-dione

: 1579952-83-2
((1R,3aR,4aS,6S,8aR,9S,9aS)-1-methyl-3-oxo-9-((E)-2-(5-(3-(trifluoromethyl)phenyl)pyridin-2-yl)vinyl)dodecahydronaphtho[2,3-c]furan-6-yl)methyl carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: phenyllithium / tetrahydrofuran / 0.5 h / -78 - 0 °C / Inert atmosphere

1.2: 2.25 h / 20 °C / Inert atmosphere

2.1: 9-borabicyclo[3.3.1]nonane / tetrahydrofuran / 5 h / 0 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

3.1: dichloromethane / 0.58 h / Inert atmosphere

3.2: 0.75 h / Inert atmosphere

With phenyllithium; 9-borabicyclo[3.3.1]nonane; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ml500008w

Reference yield:

: 1579952-81-0
(3R,3aS,4S,4aR,8aR,9aR)-3-methyl-7-methylene-4-((E)-2-(5-(3-(trifluoromethyl)phenyl)pyridin-2-yl)vinyl)decahydronaphtho[2,3-c]furan-1(3H)-one

: 1579952-83-2
((1R,3aR,4aS,6S,8aR,9S,9aS)-1-methyl-3-oxo-9-((E)-2-(5-(3-(trifluoromethyl)phenyl)pyridin-2-yl)vinyl)dodecahydronaphtho[2,3-c]furan-6-yl)methyl carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 9-borabicyclo[3.3.1]nonane / tetrahydrofuran / 5 h / 0 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: dichloromethane / 0.58 h / Inert atmosphere

2.2: 0.75 h / Inert atmosphere

With 9-borabicyclo[3.3.1]nonane; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ml500008w