5-(((3,5-bis(trifluoromethyl)benzyl)amino)methyl)-1-(tert-butyl)-N,N-bis(cyc lopropylmethyl)-3-methyl-1H-pyrazolo[3,4-b]pyridin-6-amine

Base Information

Chemical Name:5-(((3,5-bis(trifluoromethyl)benzyl)amino)methyl)-1-(tert-butyl)-N,N-bis(cyc lopropylmethyl)-3-methyl-1H-pyrazolo[3,4-b]pyridin-6-amine
CAS No.:1429200-73-6
Molecular Formula:C₂₉H₃₅F₆N₅
Molecular Weight:567.621
Hs Code.:

Synonyms:5-(((3,5-bis(trifluoromethyl)benzyl)amino)methyl)-1-(tert-butyl)-N,N-bis(cyc lopropylmethyl)-3-methyl-1H-pyrazolo[3,4-b]pyridin-6-amine

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Chemical Property of 5-(((3,5-bis(trifluoromethyl)benzyl)amino)methyl)-1-(tert-butyl)-N,N-bis(cyc lopropylmethyl)-3-methyl-1H-pyrazolo[3,4-b]pyridin-6-amine

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Technology Process of 5-(((3,5-bis(trifluoromethyl)benzyl)amino)methyl)-1-(tert-butyl)-N,N-bis(cyc lopropylmethyl)-3-methyl-1H-pyrazolo[3,4-b]pyridin-6-amine

There total 2 articles about 5-(((3,5-bis(trifluoromethyl)benzyl)amino)methyl)-1-(tert-butyl)-N,N-bis(cyc lopropylmethyl)-3-methyl-1H-pyrazolo[3,4-b]pyridin-6-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1429200-72-5
6-(bis(cyclopropylmethyl)amino)-1-(tert-butyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine-5-carbaldehyde

: 85068-29-7
3,5-bis-trifluoromethylbenzylamine

: 1429200-73-6
5-(((3,5-bis(trifluoromethyl)benzyl)amino)methyl)-1-(tert-butyl)-N,N-bis(cyc lopropylmethyl)-3-methyl-1H-pyrazolo[3,4-b]pyridin-6-amine

Guidance literature:: 6-(bis(cyclopropylmethyl)amino)-1-(tert-butyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine-5-carbaldehyde; 3,5-bis-trifluoromethylbenzylamine; With acetic acid; In methanol; at 0 ℃; for 0.333333h;

With sodium cyanoborohydride; In methanol; at 0 ℃; for 1h;

Reference yield:

: 1429200-71-4
1-(tert-butyl)-6-chloro-3-methyl-1H-pyrazolo[3,4-b]pyridine-5-carbaldehyde

: 1429200-73-6
5-(((3,5-bis(trifluoromethyl)benzyl)amino)methyl)-1-(tert-butyl)-N,N-bis(cyc lopropylmethyl)-3-methyl-1H-pyrazolo[3,4-b]pyridin-6-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / dimethyl sulfoxide / 0.5 h / 20 - 35 °C / Inert atmosphere

2.1: acetic acid / methanol / 0.33 h / 0 °C

2.2: 1 h / 0 °C

With potassium carbonate; acetic acid; In methanol; dimethyl sulfoxide;