4-amino-6-((1-(8-(3,5-difluorophenyl)-7-quinolinyl)ethyl)amino)-5-pyrimidinecarbonitrile

Base Information

Chemical Name:4-amino-6-((1-(8-(3,5-difluorophenyl)-7-quinolinyl)ethyl)amino)-5-pyrimidinecarbonitrile
CAS No.:1374193-98-2
Molecular Formula:C₂₂H₁₆F₂N₆
Molecular Weight:402.406
Hs Code.:

Synonyms:4-amino-6-((1-(8-(3,5-difluorophenyl)-7-quinolinyl)ethyl)amino)-5-pyrimidinecarbonitrile

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Chemical Property of 4-amino-6-((1-(8-(3,5-difluorophenyl)-7-quinolinyl)ethyl)amino)-5-pyrimidinecarbonitrile

Chemical Property:

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Technology Process of 4-amino-6-((1-(8-(3,5-difluorophenyl)-7-quinolinyl)ethyl)amino)-5-pyrimidinecarbonitrile

There total 7 articles about 4-amino-6-((1-(8-(3,5-difluorophenyl)-7-quinolinyl)ethyl)amino)-5-pyrimidinecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1312684-75-5
1-[8-(3,5-difluorophenyl)quinolin-7-yl]ethanamine

: 60025-09-4
4-amino-6-chloropyrimidine-5-carbonitrile

: 1374193-98-2
4-amino-6-((1-(8-(3,5-difluorophenyl)-7-quinolinyl)ethyl)amino)-5-pyrimidinecarbonitrile

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In butan-1-ol; at 110 ℃; for 19h;

Reference yield:

: 73776-20-2
8-hydroxyquinoline-7-carboxylic acid methyl ester

: 1374193-98-2
4-amino-6-((1-(8-(3,5-difluorophenyl)-7-quinolinyl)ethyl)amino)-5-pyrimidinecarbonitrile

Guidance literature:: Multi-step reaction with 8 steps

1.1: triethylamine / dmap / dichloromethane / 16 h / 20 °C

2.1: potassium phosphate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / 1,4-dioxane / 5.5 h / 100 °C / Inert atmosphere

3.1: lithium aluminium tetrahydride / diethyl ether; tetrahydrofuran / 2.5 h / 0 - 20 °C / Inert atmosphere

3.2: 0.5 h

4.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 18 h / 20 °C

5.1: titanium(IV) tetraethanolate / tetrahydrofuran / 16 h / 65 °C / Inert atmosphere

6.1: diethyl ether; tetrahydrofuran / 2.5 h / 20 °C / Cooling with acetone-dry ice; Inert atmosphere

7.1: hydrogenchloride; water / tetrahydrofuran / 1.5 h / 20 °C

8.1: N-ethyl-N,N-diisopropylamine / butan-1-ol / 19 h / 110 °C

With hydrogenchloride; titanium(IV) tetraethanolate; potassium phosphate; lithium aluminium tetrahydride; water; triethylamine; N-ethyl-N,N-diisopropylamine; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; dmap; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane; dimethyl sulfoxide; butan-1-ol;

Reference yield:

: 19829-79-9
8-hydroxy-7-quinolinecarboxylic acid

: 1374193-98-2
4-amino-6-((1-(8-(3,5-difluorophenyl)-7-quinolinyl)ethyl)amino)-5-pyrimidinecarbonitrile

Guidance literature:: Multi-step reaction with 9 steps

1.1: sulfuric acid / 14 h / Dean-Stark trap; Heating

2.1: triethylamine / dmap / dichloromethane / 16 h / 20 °C

3.1: potassium phosphate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / 1,4-dioxane / 5.5 h / 100 °C / Inert atmosphere

4.1: lithium aluminium tetrahydride / diethyl ether; tetrahydrofuran / 2.5 h / 0 - 20 °C / Inert atmosphere

4.2: 0.5 h

5.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 18 h / 20 °C

6.1: titanium(IV) tetraethanolate / tetrahydrofuran / 16 h / 65 °C / Inert atmosphere

7.1: diethyl ether; tetrahydrofuran / 2.5 h / 20 °C / Cooling with acetone-dry ice; Inert atmosphere

8.1: hydrogenchloride; water / tetrahydrofuran / 1.5 h / 20 °C

9.1: N-ethyl-N,N-diisopropylamine / butan-1-ol / 19 h / 110 °C

With hydrogenchloride; titanium(IV) tetraethanolate; potassium phosphate; lithium aluminium tetrahydride; sulfuric acid; water; triethylamine; N-ethyl-N,N-diisopropylamine; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; dmap; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane; dimethyl sulfoxide; butan-1-ol;