(+)-R-[2α,3β,5α]-2-dimethylphenylsilyl-3-hydroxy-2-hydroxymethyl-5-methyloxolane

Base Information

Chemical Name:(+)-R-[2α,3β,5α]-2-dimethylphenylsilyl-3-hydroxy-2-hydroxymethyl-5-methyloxolane
CAS No.:380228-92-2
Molecular Formula:C₁₄H₂₂O₃Si
Molecular Weight:266.412
Hs Code.:

Synonyms:(+)-R-[2α,3β,5α]-2-dimethylphenylsilyl-3-hydroxy-2-hydroxymethyl-5-methyloxolane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+)-R-[2α,3β,5α]-2-dimethylphenylsilyl-3-hydroxy-2-hydroxymethyl-5-methyloxolane

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Technology Process of (+)-R-[2α,3β,5α]-2-dimethylphenylsilyl-3-hydroxy-2-hydroxymethyl-5-methyloxolane

There total 4 articles about (+)-R-[2α,3β,5α]-2-dimethylphenylsilyl-3-hydroxy-2-hydroxymethyl-5-methyloxolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 380228-84-2
(-)-(2S,4S)-5-dimethylphenylsilyl-5-hexen-2,4-diol

: 380228-92-2
(+)-R-[2α,3β,5α]-2-dimethylphenylsilyl-3-hydroxy-2-hydroxymethyl-5-methyloxolane

Guidance literature:: With tert.-butylhydroperoxide; bis(acetylacetonate)oxovanadium; In chloroform; at 20 ℃; for 27h;
DOI:10.1021/jo010549w

Reference yield:

: (2S,4S)-5-dimethylphenylsilyl-4-hydroperoxy-5-hexen-2-ol

: 380228-92-2
(+)-R-[2α,3β,5α]-2-dimethylphenylsilyl-3-hydroxy-2-hydroxymethyl-5-methyloxolane

Guidance literature:: Multi-step reaction with 2 steps

1: triphenylphosphine / diethyl ether / 1 h / 20 °C

2: tert-butyl hydroperoxide; VO(acac)2 / CHCl₃ / 27 h / 20 °C

With tert.-butylhydroperoxide; bis(acetylacetonate)oxovanadium; triphenylphosphine; In diethyl ether; chloroform;
DOI:10.1021/jo010549w

Reference yield:

: 380228-79-5
(+)-(S)-E-5-dimethylphenylsilyl-4-hexen-2-ol

: 380228-92-2
(+)-R-[2α,3β,5α]-2-dimethylphenylsilyl-3-hydroxy-2-hydroxymethyl-5-methyloxolane

Guidance literature:: Multi-step reaction with 2 steps

1.1: O₂; tetraphenylporphyrin / CH₂Cl₂ / 2 h / -15 °C / Irradiation

1.2: Ph₃P / CH₂Cl₂ / 1 h / 20 °C

2.1: tert-butyl hydroperoxide; VO(acac)2 / CHCl₃ / 27 h / 20 °C

With tert.-butylhydroperoxide; bis(acetylacetonate)oxovanadium; oxygen; 5,15,10,20-tetraphenylporphyrin; In dichloromethane; chloroform;
DOI:10.1021/jo010549w