1-((3-tert-butyl-1-(3-fluorophenyl)-1H-pyrazol-5-yl)methyl)-3-(6-(2-(tert-butyldimethylsilyloxy)ethyl)pyridin-3-yl)urea

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Chemical Name:1-((3-tert-butyl-1-(3-fluorophenyl)-1H-pyrazol-5-yl)methyl)-3-(6-(2-(tert-butyldimethylsilyloxy)ethyl)pyridin-3-yl)urea
CAS No.:1419604-93-5
Molecular Formula:C₂₈H₄₀FN₅O₂Si
Molecular Weight:525.742
Hs Code.:

Synonyms:1-((3-tert-butyl-1-(3-fluorophenyl)-1H-pyrazol-5-yl)methyl)-3-(6-(2-(tert-butyldimethylsilyloxy)ethyl)pyridin-3-yl)urea

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Chemical Property of 1-((3-tert-butyl-1-(3-fluorophenyl)-1H-pyrazol-5-yl)methyl)-3-(6-(2-(tert-butyldimethylsilyloxy)ethyl)pyridin-3-yl)urea

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Technology Process of 1-((3-tert-butyl-1-(3-fluorophenyl)-1H-pyrazol-5-yl)methyl)-3-(6-(2-(tert-butyldimethylsilyloxy)ethyl)pyridin-3-yl)urea

There total 8 articles about 1-((3-tert-butyl-1-(3-fluorophenyl)-1H-pyrazol-5-yl)methyl)-3-(6-(2-(tert-butyldimethylsilyloxy)ethyl)pyridin-3-yl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1419602-92-8
phenyl 6-(2-(tert-butyldimethylsilyloxy)ethyl)pyridin-3-ylcarbamate

: 1419604-91-3
(3-tert-butyl-1-(3-fluorophenyl)-1H-pyrazol-5-yl)methanamine hydrochloride

: 1419604-93-5
1-((3-tert-butyl-1-(3-fluorophenyl)-1H-pyrazol-5-yl)methyl)-3-(6-(2-(tert-butyldimethylsilyloxy)ethyl)pyridin-3-yl)urea

Guidance literature:: (3-tert-butyl-1-(3-fluorophenyl)-1H-pyrazol-5-yl)methanamine hydrochloride; With triethylamine; In dichloromethane; at 23 ℃; for 0.166667h;

phenyl 6-(2-(tert-butyldimethylsilyloxy)ethyl)pyridin-3-ylcarbamate; In dichloromethane; at 23 ℃; for 16h;

Reference yield:

: 5418-51-9
5-nitro-2-hydroxypyridine

: 1419604-93-5
1-((3-tert-butyl-1-(3-fluorophenyl)-1H-pyrazol-5-yl)methyl)-3-(6-(2-(tert-butyldimethylsilyloxy)ethyl)pyridin-3-yl)urea

Guidance literature:: Multi-step reaction with 8 steps

1.1: trichlorophosphate; phosphorus pentachloride / 16 h / 60 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 70 °C

3.1: sodium chloride; water / dimethyl sulfoxide / 2 h / 120 °C

4.1: diisobutylaluminium hydride / tetrahydrofuran / 2 h / -78 °C

5.1: 1H-imidazole / dichloromethane / 0 - 23 °C

6.1: palladium 10% on activated carbon; hydrogen / methanesulfonic acid / 2 h / 23 °C

7.1: pyridine / acetone / 2 h / 23 °C

8.1: triethylamine / dichloromethane / 0.17 h / 23 °C

8.2: 16 h / 23 °C

With pyridine; 1H-imidazole; phosphorus pentachloride; palladium 10% on activated carbon; water; hydrogen; diisobutylaluminium hydride; potassium carbonate; triethylamine; sodium chloride; trichlorophosphate; In tetrahydrofuran; methanesulfonic acid; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone;

Reference yield:

: 4548-45-2
2-chloro-5-nitropyridine

: 1419604-93-5
1-((3-tert-butyl-1-(3-fluorophenyl)-1H-pyrazol-5-yl)methyl)-3-(6-(2-(tert-butyldimethylsilyloxy)ethyl)pyridin-3-yl)urea

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 70 °C

2.1: sodium chloride; water / dimethyl sulfoxide / 2 h / 120 °C

3.1: diisobutylaluminium hydride / tetrahydrofuran / 2 h / -78 °C

4.1: 1H-imidazole / dichloromethane / 0 - 23 °C

5.1: palladium 10% on activated carbon; hydrogen / methanesulfonic acid / 2 h / 23 °C

6.1: pyridine / acetone / 2 h / 23 °C

7.1: triethylamine / dichloromethane / 0.17 h / 23 °C

7.2: 16 h / 23 °C

With pyridine; 1H-imidazole; palladium 10% on activated carbon; water; hydrogen; diisobutylaluminium hydride; potassium carbonate; triethylamine; sodium chloride; In tetrahydrofuran; methanesulfonic acid; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone;