7-ACETOXY-6-METHOXY-3,4-DIHYDROQUINAZODIN-4-ONE

Base Information

• Chemical Name: 7-ACETOXY-6-METHOXY-3,4-DIHYDROQUINAZODIN-4-ONE
• CAS No.: 179688-02-9
• Molecular Formula: C11H10 N2 O4
• Molecular Weight: 234.21
• Mol file: 179688-02-9.mol

Synonyms:4(1H)-Quinazolinone,7-(acetyloxy)-6-methoxy- (9CI); 7-(Acetoxy)-6-methoxyquinazolin-4(3H)-one;7-(acetoxy)-6-methoxyquinazolin-4(3H)-one;7-Acetoxy-6-methoxy-3,4-dihydroquinazolin-4-one

Chemical Property of 7-ACETOXY-6-METHOXY-3,4-DIHYDROQUINAZODIN-4-ONE

Chemical Property:

• Vapor Pressure: 2.79E-09mmHg at 25°C
• Refractive Index: 1.61
• Boiling Point: 477.5°Cat760mmHg
• Flash Point: 242.6°C
• PSA: 81.28000
• Density: 1.3g/cm³
• LogP: 0.85700

Purity/Quality:

99% ^*data from raw suppliers

7-ACETOXY-6-METHOXY-3,4-DIHYDROQUINAZODIN-4-ONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-ACETOXY-6-METHOXY-3,4-DIHYDROQUINAZODIN-4-ONE

There total 8 articles about 7-ACETOXY-6-METHOXY-3,4-DIHYDROQUINAZODIN-4-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

7-hydroxy-6-methoxy-3,4-dihydroquinazolin-4-one (162012-72-8) + acetic anhydride (108-24-7) → 7-acetoxy-6-methoxy-3,4-dihydroquinazolin-4-one (179688-02-9)

Guidance literature:

With pyridine; at 90 ℃; for 2h;

DOI:10.1016/j.bmc.2014.10.038

Reference yield: 27.0%

7-(benzyloxy)-6-methoxyquinazolin-4(3H)-one (179688-01-8) → 7-acetoxy-6-methoxy-3,4-dihydroquinazolin-4-one (179688-02-9)

Guidance literature:

With sodium acetate; acetic anhydride; palladium; In methanol; water; ethyl acetate; toluene;

Reference yield:

7-hydroxy-6-methoxy-3,4-dihydroquinazolin-4-one (162012-72-8) → 7-acetoxy-6-methoxy-3,4-dihydroquinazolin-4-one (179688-02-9)

Guidance literature:

7-hydroxy-6-methoxy-3,4-dihydroquinazolin-4-one; With pyridine; acetic anhydride; at 20 ℃; for 16h;

With pyridine; water; In water; at 90 ℃; for 0.25h;

upstream raw materials:

7-hydroxy-6-methoxy-3,4-dihydroquinazolin-4-one

acetic anhydride

7-(benzyloxy)-6-methoxyquinazolin-4(3H)-one

4-hydroxy-3-methoxybenzoic acid methyl ester

Downstream raw materials:

4-chloro-6-methoxyquinazolin-7-yl acetate

4-((3-chloro-4-fluorophenyl)amino)-6-methoxyquinazolin-7-ol

acetic acid 4-(3-chloro-4-fluoro-phenylamino)-6-methoxy-quinazolin-7-yl ester

trifluoromethanesulfonic acid 4-(3-chloro-4-fluorophenylamino)-6-methoxy-7-quinazolinyl ester