methyl (3S,4R)-3-(N-benzylhydroxyamino)-4-(tert-butoxycarbonylamino)-5-hydroxy-5-(tert-butyldiphenylsiloxy)pentanoate

Base Information

• Chemical Name: methyl (3S,4R)-3-(N-benzylhydroxyamino)-4-(tert-butoxycarbonylamino)-5-hydroxy-5-(tert-butyldiphenylsiloxy)pentanoate
• CAS No.: 298198-08-0
• Molecular Formula: C₃₄H₄₆N₂O₆Si
• Molecular Weight: 606.835

Synonyms:methyl (3S,4R)-3-(N-benzylhydroxyamino)-4-(tert-butoxycarbonylamino)-5-hydroxy-5-(tert-butyldiphenylsiloxy)pentanoate

Chemical Property of methyl (3S,4R)-3-(N-benzylhydroxyamino)-4-(tert-butoxycarbonylamino)-5-hydroxy-5-(tert-butyldiphenylsiloxy)pentanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl (3S,4R)-3-(N-benzylhydroxyamino)-4-(tert-butoxycarbonylamino)-5-hydroxy-5-(tert-butyldiphenylsiloxy)pentanoate

There total 2 articles about methyl (3S,4R)-3-(N-benzylhydroxyamino)-4-(tert-butoxycarbonylamino)-5-hydroxy-5-(tert-butyldiphenylsiloxy)pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

N-benzylhydroxylamine hydrochloride (29601-98-7) + (E)-(R)-4-tert-Butoxycarbonylamino-5-(tert-butyl-diphenyl-silanyloxy)-pent-2-enoic acid methyl ester → methyl (3S,4R)-3-(N-benzylhydroxyamino)-4-(tert-butoxycarbonylamino)-5-hydroxy-5-(tert-butyldiphenylsiloxy)pentanoate (298198-08-0) + methyl (3R,4R)-3-(N-benzylhydroxyamino)-4-(tert-butoxycarbonylamino)-5-hydroxy-5-(tert-butyldiphenylsiloxy)pentanoate (298198-09-1)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 12h;

DOI:10.1021/jo0002689

Reference yield: 26.0%

N-benzylhydroxylamine hydrochloride (29601-98-7) + (Z)-(R)-4-tert-Butoxycarbonylamino-5-(tert-butyl-diphenyl-silanyloxy)-pent-2-enoic acid methyl ester → methyl (3S,4R)-3-(N-benzylhydroxyamino)-4-(tert-butoxycarbonylamino)-5-hydroxy-5-(tert-butyldiphenylsiloxy)pentanoate (298198-08-0) + methyl (3R,4R)-3-(N-benzylhydroxyamino)-4-(tert-butoxycarbonylamino)-5-hydroxy-5-(tert-butyldiphenylsiloxy)pentanoate (298198-09-1)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 12h;

DOI:10.1021/jo0002689

Reference yield: 95.0%

methyl (3S,4R)-3-(N-benzylhydroxyamino)-4-(tert-butoxycarbonylamino)-5-hydroxy-5-(tert-butyldiphenylsiloxy)pentanoate (298198-08-0) → (3S)-2-benzyl-3-[(1R)-1-(tert-butoxycarbonylamino)-2-(tert-butyldiphenylsiloxy)ethyl]isoxazolidin-5-one (220335-98-8)

Guidance literature:

With sodium methylate; In methanol; at 20 ℃; for 2h;

DOI:10.1021/jo0002689

upstream raw materials:

N-benzylhydroxylamine hydrochloride

Downstream raw materials:

(3S)-2-benzyl-3-[(1R)-1-(tert-butoxycarbonylamino)-2-(tert-butyldiphenylsiloxy)ethyl]isoxazolidin-5-one

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 298198-08-0 methyl (3S,4R)-3-(N-benzylhydroxyamino)-4-(tert-butoxycarbonylamino)-5-hydroxy-5-(tert-butyldiphenylsiloxy)pentanoate

Send

Send

Metric Ton KG G Pound L ML

Send

Send