Acetic acid 2-{(2R,3R,3aR,9aR)-2-[4-(2,6-dimethyl-phenoxy)-2-oxo-2H-pyrimidin-1-yl]-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-yloxy}-ethyl ester

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Chemical Name:Acetic acid 2-{(2R,3R,3aR,9aR)-2-[4-(2,6-dimethyl-phenoxy)-2-oxo-2H-pyrimidin-1-yl]-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-yloxy}-ethyl ester
CAS No.:647839-11-0
Molecular Formula:C₃₃H₅₂N₂O₉Si₂
Molecular Weight:676.955
Hs Code.:

Acetic acid 2-{(2R,3R,3aR,9aR)-2-[4-(2,6-dimethyl-phenoxy)-2-oxo-2H-pyrimidin-1-yl]-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-yloxy}-ethyl ester

Synonyms:Acetic acid 2-{(2R,3R,3aR,9aR)-2-[4-(2,6-dimethyl-phenoxy)-2-oxo-2H-pyrimidin-1-yl]-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-yloxy}-ethyl ester

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Chemical Property of Acetic acid 2-{(2R,3R,3aR,9aR)-2-[4-(2,6-dimethyl-phenoxy)-2-oxo-2H-pyrimidin-1-yl]-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-yloxy}-ethyl ester

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Technology Process of Acetic acid 2-{(2R,3R,3aR,9aR)-2-[4-(2,6-dimethyl-phenoxy)-2-oxo-2H-pyrimidin-1-yl]-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-yloxy}-ethyl ester

There total 7 articles about Acetic acid 2-{(2R,3R,3aR,9aR)-2-[4-(2,6-dimethyl-phenoxy)-2-oxo-2H-pyrimidin-1-yl]-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-yloxy}-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 108-24-7
acetic anhydride

: 647839-10-9
4-(2,6-Dimethyl-phenoxy)-1-[(2R,3R,3aR,9aR)-3-(2-hydroxy-ethoxy)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-1H-pyrimidin-2-one

: 647839-11-0
Acetic acid 2-{(2R,3R,3aR,9aR)-2-[4-(2,6-dimethyl-phenoxy)-2-oxo-2H-pyrimidin-1-yl]-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-yloxy}-ethyl ester

Guidance literature:: With pyridine; at 20 ℃;
DOI:10.1021/jo035246b

Reference yield:

: 576-26-1,25134-01-4
2.6-dimethylphenol

: 647839-11-0
Acetic acid 2-{(2R,3R,3aR,9aR)-2-[4-(2,6-dimethyl-phenoxy)-2-oxo-2H-pyrimidin-1-yl]-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-yloxy}-ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: aq. Na₂CO₃; tetrabutylammonium bromide; 2,4,6-triisopropylbenzenesulfonyl chloride / CH₂Cl₂ / 15 h / 20 °C

1.2: 92 percent / Et₃N; 1,4-diazabicyclo[2,2,2]octane / acetonitrile / 0.5 h / 20 °C

2.1: 97 percent / Ph₃P; tris(dibenzylideneacetone)-dipalladium⁽⁰⁾ / tetrahydrofuran / 0.5 h / Heating

3.1: 100 percent / N-methylmorpholine N-oxide; OsO₄ / acetone; H₂O / 20 h / 20 °C

4.1: 98 percent / NaIO₄ / dioxane; H₂O / 20 °C

5.1: 86 percent / NaBH₄ / methanol / 20 °C

6.1: 91 percent / pyridine / 20 °C

With pyridine; sodium tetrahydroborate; sodium periodate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; osmium(VIII) oxide; 2,4,6-triisopropylphenylsulfonyl chloride; tetrabutylammomium bromide; sodium carbonate; 4-methylmorpholine N-oxide; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; acetone;
DOI:10.1021/jo035246b

Reference yield:

: 69304-38-7
3',5'-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine

: 647839-11-0
Acetic acid 2-{(2R,3R,3aR,9aR)-2-[4-(2,6-dimethyl-phenoxy)-2-oxo-2H-pyrimidin-1-yl]-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-yloxy}-ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: aq. Na₂CO₃; tetrabutylammonium bromide; 2,4,6-triisopropylbenzenesulfonyl chloride / CH₂Cl₂ / 15 h / 20 °C

1.2: 92 percent / Et₃N; 1,4-diazabicyclo[2,2,2]octane / acetonitrile / 0.5 h / 20 °C

2.1: 97 percent / Ph₃P; tris(dibenzylideneacetone)-dipalladium⁽⁰⁾ / tetrahydrofuran / 0.5 h / Heating

3.1: 100 percent / N-methylmorpholine N-oxide; OsO₄ / acetone; H₂O / 20 h / 20 °C

4.1: 98 percent / NaIO₄ / dioxane; H₂O / 20 °C

5.1: 86 percent / NaBH₄ / methanol / 20 °C

6.1: 91 percent / pyridine / 20 °C

With pyridine; sodium tetrahydroborate; sodium periodate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; osmium(VIII) oxide; 2,4,6-triisopropylphenylsulfonyl chloride; tetrabutylammomium bromide; sodium carbonate; 4-methylmorpholine N-oxide; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; acetone;
DOI:10.1021/jo035246b